An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo
Sanchez-Aguilera, A., Wheeler, D. W., Jurado-Parras, T., Valero, M., Nokia, M. S., Cid, E., Fernandez-Lamo, I., Sutton, N., García-Rincón, D., de la Prida, L. M., & Ascoli, G. A. (2021). An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo. PLoS Biology, 19(5), Article e3001213. https://doi.org/10.1371/journal.pbio.3001213
Published inPLoS Biology
DisciplinePsykologiaMonitieteinen aivotutkimuskeskusHyvinvoinnin tutkimuksen yhteisöPsychologyCentre for Interdisciplinary Brain ResearchSchool of Wellbeing
© 2021 Sanchez-Aguilera et al.
Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping of firing behavior during ongoing oscillations in vivo has provided a large body of evidence on entorhinal–hippocampal function, but data are dispersed and diverse. Here, we mined literature to search for information regarding the phase-timing dynamics of over 100 hippocampal/entorhinal neuron types defined in Hippocampome.org. We identified missing and unresolved pieces of knowledge (e.g., the preferred theta phase for a specific neuron type) and complemented the dataset with our own new data. By confronting the effect of brain state and recording methods, we highlight the equivalences and differences across conditions and offer a number of novel observations. We show how a heuristic approach based on oscillatory features of morphologically identified neurons can aid in classifying extracellular recordings of single cells and discuss future opportunities and challenges towards integrating single-cell phenotypes with circuit function. ...
PublisherPublic Library of Science (PLoS)
Publication in research information system
MetadataShow full item record
Related funder(s)Academy of Finland
Funding program(s)Research costs of Academy Research Fellow, AoF; Academy Research Fellow, AoF
Additional information about fundingThe authors received funding from the following sources: 1: National Institutes of Health (https://www.nih.gov/grants-funding) (R01NS39600 and U01MH114829) [GAA] 2: Spanish Ministerio de Economía y Competitividad (MINECO) (https://portal.mineco.gob.es/en-us/Pages/default.aspx) (RTI2018-098581-B-I00 and FJCI-2017-32719) [LMP and ASA] 3: Academy of Finland (https://www.aka.fi/en/) (grant nr. 275954) [MSN] 4: European Molecular Biology Organization (https://www.embo.org/funding-awards/fellowships) (EMBO ALTF 1161-2017) [MV] 5: Human Frontiers Science Program (https://www.hfsp.org/funding/hfsp-funding/) (LT0000717/2018) [MV] The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ...
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