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dc.contributor.authorZhao, Tong
dc.contributor.authorLe, Shenglong
dc.contributor.authorFreitag, Nils
dc.contributor.authorSchumann, Moritz
dc.contributor.authorWang, Xiuqiang
dc.contributor.authorCheng, Sulin
dc.date.accessioned2021-04-07T06:29:47Z
dc.date.available2021-04-07T06:29:47Z
dc.date.issued2021
dc.identifier.citationZhao, T., Le, S., Freitag, N., Schumann, M., Wang, X., & Cheng, S. (2021). Effect of Chronic Exercise Training on Blood Lactate Metabolism Among Patients With Type 2 Diabetes Mellitus : A Systematic Review and Meta-Analysis. <i>Frontiers in Physiology</i>, <i>12</i>. https://doi.org/10.3389/fphys.2021.652023
dc.identifier.otherCONVID_62894248
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/74972
dc.description.abstractPurpose: To assess the effect of chronic exercise training on blood lactate metabolism at rest (i.e., basal lactate concentrations) and during exercise (i.e., blood lactate concentration at a fixed load, load at a fixed blood lactate concentration, and load at the individual blood lactate threshold) among patients with type 2 diabetes mellitus (T2DM). Methods: PubMed (MedLine), Embase, Web of Science, and Scopus were searched. Randomized controlled trials, non-randomized controlled trials, and case-control studies using chronic exercise training (i.e., 4 weeks) and that assessed blood lactate concentrations at rest and during exercise in T2DM patients were included. Results: Thirteen studies were eligible for the systematic review, while 12 studies with 312 participants were included into the meta-analysis. In the pre-to-post intervention meta-analysis, chronic exercise training had no significant effect on changes in basal blood lactate concentrations (standardized mean difference (SMD) = -0.20; 95% CI, -0.55 to 0.16; p = 0.28), and the results were similar when comparing the effect of intervention and control groups. Furthermore, blood lactate concentration at a fixed load significantly decreased (SMD = -0.73; 95% CI, -1.17 to -0.29; p = 0.001), while load at a fixed blood lactate concentration increased (SMD = 0.40; 95% CI, 0.07 to 0.72; p = 0.02) after chronic exercise training. No change was observed in load at the individual blood lactate threshold (SMD = 0.28; 95% CI, -0.14 to 0.71; p = 0.20). Conclusion: Chronic exercise training does not statistically affect basal blood lactate concentrations; however, it may decrease the blood lactate concentrations during exercise, indicating improvements of physical performance capacity which is beneficial for T2DM patients' health in general. Why chronic exercise training did not affect basal blood lactate concentrations needs further investigation.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.relation.ispartofseriesFrontiers in Physiology
dc.rightsCC BY 4.0
dc.subject.otherT2DM
dc.subject.otherhyperlactatemia
dc.subject.otherlactate threshold
dc.subject.otherlactic acid
dc.subject.otherphysical training
dc.subject.othersports medicine
dc.titleEffect of Chronic Exercise Training on Blood Lactate Metabolism Among Patients With Type 2 Diabetes Mellitus : A Systematic Review and Meta-Analysis
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202104072294
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn1664-042X
dc.relation.volume12
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysoaineenvaihduntahäiriöt
dc.subject.ysomarkkerit
dc.subject.ysokuntoliikunta
dc.subject.ysolaktaatit
dc.subject.ysoaikuistyypin diabetes
dc.subject.ysoaineenvaihdunta
dc.subject.ysofysiologiset vaikutukset
dc.subject.ysometa-analyysi
dc.subject.ysosystemaattiset kirjallisuuskatsaukset
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p6239
jyx.subject.urihttp://www.yso.fi/onto/yso/p12288
jyx.subject.urihttp://www.yso.fi/onto/yso/p3708
jyx.subject.urihttp://www.yso.fi/onto/yso/p9014
jyx.subject.urihttp://www.yso.fi/onto/yso/p8303
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
jyx.subject.urihttp://www.yso.fi/onto/yso/p11511
jyx.subject.urihttp://www.yso.fi/onto/yso/p27697
jyx.subject.urihttp://www.yso.fi/onto/yso/p29683
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3389/fphys.2021.652023
jyx.fundinginformationThis study was funded by the start-up plan for new young teachers grant (Grant AF4150043) and by the 111 Project (B17029) at Shanghai Jiao Tong University.


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