Show simple item record

dc.contributor.authorSeppälä, Toni T.
dc.contributor.authorDominguez-Valentin, Mev
dc.contributor.authorCrosbie, Emma J.
dc.contributor.authorEngel, Christoph
dc.contributor.authorAretz, Stefan
dc.contributor.authorMacrae, Finlay
dc.contributor.authorWinship, Ingrid
dc.contributor.authorCapella, Gabriel
dc.contributor.authorThomas, Huw
dc.contributor.authorHovig, Eivind
dc.contributor.authorNielsen, Maartje
dc.contributor.authorSijmons, Rolf H.
dc.contributor.authorBertario, Lucio
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorTibiletti, Maria G.
dc.contributor.authorCavestro, Giulia M.
dc.contributor.authorMints, Miriam
dc.contributor.authorGluck, Nathan
dc.contributor.authorKatz, Lior
dc.contributor.authorHeinimann, Karl
dc.contributor.authorVaccaro, Carlos A.
dc.contributor.authorGreen, Kate
dc.contributor.authorLalloo, Fiona
dc.contributor.authorHill, James
dc.contributor.authorSchmiegel, Wolff
dc.contributor.authorVangala, Deepak
dc.contributor.authorPerne, Claudia
dc.contributor.authorStrauß, Hans-Georg
dc.contributor.authorTecklenburg, Johanna
dc.contributor.authorHolinski-Feder, Elke
dc.contributor.authorSteinke-Lange, Verena
dc.contributor.authorMecklin, Jukka-Pekka
dc.contributor.authorPlazzer, John-Paul
dc.contributor.authorPineda, Marta
dc.contributor.authorNavarro, Matilde
dc.contributor.authorVida, Joan B.
dc.contributor.authorKariv, Revital
dc.contributor.authorRosner, Guy
dc.contributor.authorPiñero, Tamara A.
dc.contributor.authorPavicic, Walter
dc.contributor.authorKalfayan, Pablo
dc.contributor.authorten Broeke, Sanne W.
dc.contributor.authorJenkins, Mark A.
dc.contributor.authorSunde, Lone
dc.contributor.authorBernstein, Inge
dc.contributor.authorBurn, John
dc.contributor.authorGreenblatt, Marc
dc.contributor.authorde Vos tot Nederveen Cappel, Wouter H.
dc.contributor.authorDella Valle, Adriana
dc.contributor.authorLopez-Koestner, Francisco
dc.contributor.authorAlvarez, Karin
dc.contributor.authorBüttner, Reinhard
dc.contributor.authorGörgens, Heike
dc.contributor.authorMorak, Monika
dc.contributor.authorHolzapfel, Stefanie
dc.contributor.authorHüneburg, Robert
dc.contributor.authorvon Knebel Doeberitz, Magnus
dc.contributor.authorLoeffler, Markus
dc.contributor.authorRedler, Silke
dc.contributor.authorWeitz, Jürgen
dc.contributor.authorPylvänäinen, Kirsi
dc.contributor.authorRenkonen-Sinisalo, Laura
dc.contributor.authorLepistö, Anna
dc.contributor.authorHopper, John L.
dc.contributor.authorWin, Aung K.
dc.contributor.authorLindor, Noralane M.
dc.contributor.authorGallinger, Steven
dc.contributor.authorLe Marchand, Loïc
dc.contributor.authorNewcomb, Polly A.
dc.contributor.authorFigueiredo, Jane C.
dc.contributor.authorThibodeau, Stephen N.
dc.contributor.authorTherkildsen, Christina
dc.contributor.authorWadt, Karin A.W.
dc.contributor.authorMourits, Marian J.E.
dc.contributor.authorKetabi, Zohreh
dc.contributor.authorDenton, Oliver G.
dc.contributor.authorRødland, Einar A.
dc.contributor.authorVasen, Hans
dc.contributor.authorNeffa, Florencia
dc.contributor.authorEsperon, Patricia
dc.contributor.authorTjandra, Douglas
dc.contributor.authorMöslein, Gabriela
dc.contributor.authorRokkones, Erik
dc.contributor.authorSampson, Julian R.
dc.contributor.authorEvans, D.G.
dc.contributor.authorMøller, Pål
dc.identifier.citationSeppälä, T. T., Dominguez-Valentin, M., Crosbie, E. J., Engel, C., Aretz, S., Macrae, F., Winship, I., Capella, G., Thomas, H., Hovig, E., Nielsen, M., Sijmons, R. H., Bertario, L., Bonanni, B., Tibiletti, M. G., Cavestro, G. M., Mints, M., Gluck, N., Katz, L., . . . Møller, P. (2021). Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants : a Prospective Lynch Syndrome Database report. <i>European Journal of Cancer</i>, <i>148</i>, 124-133. <a href="" target="_blank"></a>
dc.description.abstractPurpose This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. Methods The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30–69 years. Results Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. Conclusion Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syndrome to improve outcomes.en
dc.relation.ispartofseriesEuropean Journal of Cancer
dc.rightsCC BY 4.0
dc.subject.otherLynch syndrome
dc.subject.otherendometrial cancer
dc.subject.otherovarian cancer
dc.subject.otherrisk-reducing surgery
dc.titleUptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants : a Prospective Lynch Syndrome Database report
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.rights.copyright© 2021 The Author(s). Published by Elsevier Ltd.
dc.subject.ysokohdunrungon syöpä
dc.subject.ysoLynchin oireyhtymä
jyx.fundinginformationThe study was supported by a “Pink ribbon” grant #194751 from Den Norske Kreftforening to EH. The authors would like to express our gratitude to Heikki Järvinen, Beatrice Alcala-Repo, Teresa Ocaña, María Pellisé, Sabela Carballal, Liseth Rivero, Lorena Moreno, Gerhard Jung, Antoni Castells, Joaquin Cubiella, Laura Rivas, Luis Bujanda, Inés Gil, Jesús Bañales, Catalina Garau, Rodrigo Jover, María Dolores Picó, Xavier Bessa, Cristina Álvarez, Montserrat Andreu, Carmen Poves, Pedro Pérez Segura, Lucía Cid, Marta Carrillo, Enrique Quintero, Ángeles Pizarro, Marta Garzón, Adolfo Suárez, Inmaculada Salces, Daniel Rodriguez-Alcalde, Judith Balmaña, Adrià López, Nuria Dueñas, Gemma Llort, Carmen Yagüe, Teresa Ramón i Cajal, David Fisas Masferrer, Alexandra Gisbert Beamud, Consol López San Martín, Maite Herráiz, Pilar Pérez, Cristina Carretero, Maite Betés, Marta Ponce, Elena Aguirre, Nora Alfaro, Carlos Sarroca, and Marianne Haeusler for their efforts over many years. The CCFR graciously thanks the generous contributions of their study participants and dedication of study staff. The authors would also like to thank Cancer Foundation Finland, Jane and Aatos Erkko Foundation, Emil Aaltonen Foundation, Finnish Medical Foundation, Sigrid Juselius Foundation, Instrumentarium Science Foundation, iCAN Flagship of the Academy of Finland, and the Norwegian Cancer Society, contract 194751-2017, for funding. DGE and EJC are supported by the All Manchester National Institute for Health Research (NIHR) Biomedical Research Centre (IS-BRC-1215-20007) and JRS by Health and Care Research Wales through Wales Gene Park. The CCFR is supported in part by the National Cancer Institute of the National Institutes of Health under Award Number UM1CA167551. The German Consortium for Familial Intestinal Cancer has been supported by grants from the German Cancer Aid. Data collection from Wales, UK, was supported by the Wales Gene Park. This work was co-funded by the European Regional Development Fund (ERDF). MN and StB were supported by a grant from the Dutch Cancer Society (DCS), grant number UL 2017-8223. Gabriel Capella, Marta Pineda, and Joan Brunet were funded by the Spanish Ministry of Economy and Competitiveness and co-funded by FEDER funds, a way to build Europe (grant SAF2015-68016-R), CIBERONC, and the Government of Catalonia (grant 2017SGR1282). The authors thank CERCA Programme/Generalitat de Catalunya for institutional support. The work was also partially supported by the Italian Ministry of Health with Ricerca Corrente and 5×1000 funds.

Files in this item


This item appears in the following Collection(s)

Show simple item record

CC BY 4.0
Except where otherwise noted, this item's license is described as CC BY 4.0