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dc.contributor.authorAhadova, Aysel
dc.contributor.authorSeppälä, Toni T.
dc.contributor.authorEngel, Christoph
dc.contributor.authorGallon, Richard
dc.contributor.authorBurn, John
dc.contributor.authorHolinski‐Feder, Elke
dc.contributor.authorSteinke‐Lange, Verena
dc.contributor.authorMöslein, Gabriela
dc.contributor.authorNielsen, Maartje
dc.contributor.authorten Broeke, Sanne
dc.contributor.authorLaghi, Luigi
dc.contributor.authorDominguez‐Valentin, Mev
dc.contributor.authorCapella, Gabriel
dc.contributor.authorMacrae, Finlay
dc.contributor.authorScott, Rodney
dc.contributor.authorHüneburg, Robert
dc.contributor.authorNattermann, Jacob
dc.contributor.authorHoffmeister, Michael
dc.contributor.authorBrenner, Hermann
dc.contributor.authorBläker, Hendrik
dc.contributor.authorvon Knebel Doeberit,z Magnus
dc.contributor.authorSampson, Julian R.
dc.contributor.authorVasen, Hans
dc.contributor.authorMecklin, Jukka‐Pekka
dc.contributor.authorMøller, Pål
dc.contributor.authorKloor, Matthias
dc.date.accessioned2021-02-15T08:15:46Z
dc.date.available2021-02-15T08:15:46Z
dc.date.issued2021
dc.identifier.citationAhadova, A., Seppälä, T. T., Engel, C., Gallon, R., Burn, J., Holinski‐Feder, E., Steinke‐Lange, V., Möslein, G., Nielsen, M., ten Broeke, S., Laghi, L., Dominguez‐Valentin, M., Capella, G., Macrae, F., Scott, R., Hüneburg, R., Nattermann, J., Hoffmeister, M., Brenner, H., . . . Kloor, M. (2021). The “unnatural” history of colorectal cancer in Lynch syndrome : lessons from colonoscopy surveillance. <i>International Journal of Cancer</i>, <i>148</i>(4), 800-811. <a href="https://doi.org/10.1002/ijc.33224" target="_blank">https://doi.org/10.1002/ijc.33224</a>
dc.identifier.otherCONVID_41622602
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/74219
dc.description.abstractIndividuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS‐associated CRC. Alongside with hypotheses addressing colonoscopy quality and pace of progression from adenoma to cancer, we discuss the role of alternative precursors and of immune system in LS‐associated CRC. We also identify gaps in current knowledge and make suggestions for future studies aiming at improved CRC prevention for LS individuals.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofseriesInternational Journal of Cancer
dc.rightsCC BY-NC-ND 4.0
dc.subject.otherLynch syndrome
dc.subject.othercolorectal cancer
dc.subject.othercolonoscopy surveillance
dc.subject.otherincident cancer risk
dc.subject.othermismatch repair deficiency
dc.subject.othermicrosatellite instability
dc.titleThe “unnatural” history of colorectal cancer in Lynch syndrome : lessons from colonoscopy surveillance
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202102151646
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange800-811
dc.relation.issn0020-7136
dc.relation.numberinseries4
dc.relation.volume148
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysoperinnölliset taudit
dc.subject.ysoseulontatutkimus
dc.subject.ysosuolistosyövät
dc.subject.ysopaksusuolisyöpä
dc.subject.ysosyöpätaudit
dc.subject.ysokoloskopia
dc.subject.ysoLynchin oireyhtymä
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p19997
jyx.subject.urihttp://www.yso.fi/onto/yso/p14972
jyx.subject.urihttp://www.yso.fi/onto/yso/p25845
jyx.subject.urihttp://www.yso.fi/onto/yso/p5937
jyx.subject.urihttp://www.yso.fi/onto/yso/p678
jyx.subject.urihttp://www.yso.fi/onto/yso/p1078
jyx.subject.urihttp://www.yso.fi/onto/yso/p23697
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1002/ijc.33224


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