Angular Regioselectivity in the Reactions of 2-Thioxopyrimidin-4-ones and Hydrazonoyl Chlorides : Synthesis of Novel Stereoisomeric Octahydro[1,2,4]triazolo[4,3-a]quinazolin-5-ones
| dc.contributor.author | Said, Awad I. | |
| dc.contributor.author | Palkó, Márta | |
| dc.contributor.author | Haukka, Matti | |
| dc.contributor.author | Fülöp, Ferenc | |
| dc.date.accessioned | 2020-12-23T08:30:38Z | |
| dc.date.available | 2020-12-23T08:30:38Z | |
| dc.date.issued | 2020 | |
| dc.identifier.citation | Said, A. I., Palkó, M., Haukka, M., & Fülöp, F. (2020). Angular Regioselectivity in the Reactions of 2-Thioxopyrimidin-4-ones and Hydrazonoyl Chlorides : Synthesis of Novel Stereoisomeric Octahydro[1,2,4]triazolo[4,3-a]quinazolin-5-ones. <i>Molecules</i>, <i>25</i>(23), Article 5673. <a href="https://doi.org/10.3390/molecules25235673" target="_blank">https://doi.org/10.3390/molecules25235673</a> | |
| dc.identifier.other | CONVID_47466044 | |
| dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/73402 | |
| dc.description.abstract | The regioselective synthesis of cis and trans stereoisomers of variously functionalized octahydro[1,2,4]triazolo[4,3-a]quinazolin-5-ones was performed. The 2-thioxopyrimidin-4-ones used in the synthesis reacted with hydrazonoyl chlorides in a regioselective manner to produce the angular regioisomers [1,2,4]triazolo[4,3-a]quinazolin-5-ones rather than the linear isomers [1,2,4]triazolo[4,3-a]quinazolin-5-ones. The synthesis process took place with electronic control. The angular regiochemistry of the products was confirmed by X-ray experiments and two-dimensional NMR studies. | en |
| dc.format.mimetype | application/pdf | |
| dc.language | eng | |
| dc.language.iso | eng | |
| dc.publisher | MDPI | |
| dc.relation.ispartofseries | Molecules | |
| dc.rights | CC BY 4.0 | |
| dc.subject.other | regioselective reactions | |
| dc.subject.other | hydrazonoyl chlorides | |
| dc.subject.other | 2-thioxopyrimidin-4-ones | |
| dc.subject.other | [1,2,4]triazolo[4,3-a]quinazolin-5-ones | |
| dc.title | Angular Regioselectivity in the Reactions of 2-Thioxopyrimidin-4-ones and Hydrazonoyl Chlorides : Synthesis of Novel Stereoisomeric Octahydro[1,2,4]triazolo[4,3-a]quinazolin-5-ones | |
| dc.type | research article | |
| dc.identifier.urn | URN:NBN:fi:jyu-202012237343 | |
| dc.contributor.laitos | Kemian laitos | fi |
| dc.contributor.laitos | Department of Chemistry | en |
| dc.contributor.oppiaine | Epäorgaaninen kemia | fi |
| dc.contributor.oppiaine | Epäorgaaninen ja analyyttinen kemia | fi |
| dc.contributor.oppiaine | Inorganic Chemistry | en |
| dc.contributor.oppiaine | Inorganic and Analytical Chemistry | en |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
| dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.description.reviewstatus | peerReviewed | |
| dc.relation.issn | 1420-3049 | |
| dc.relation.numberinseries | 23 | |
| dc.relation.volume | 25 | |
| dc.type.version | publishedVersion | |
| dc.rights.copyright | © 2020 the Authors | |
| dc.rights.accesslevel | openAccess | fi |
| dc.type.publication | article | |
| dc.subject.yso | orgaaniset yhdisteet | |
| dc.subject.yso | kemiallinen synteesi | |
| dc.subject.yso | isomeria | |
| dc.subject.yso | typpiyhdisteet | |
| dc.format.content | fulltext | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p3841 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p8468 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p10129 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p640 | |
| dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
| dc.relation.doi | 10.3390/molecules25235673 | |
| jyx.fundinginformation | We are grateful to the Hungarian Research Foundation (OTKA No. K 115731). The financial support of the GINOP-2.3.2-15-2016-00014 project is acknowledged. The Ministry of Human Capacities, Hungary, grant TUDFO/47138-1/2019, is acknowledged. | |
| dc.type.okm | A1 |
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