Show simple item record

dc.contributor.authorPu, Lanlan
dc.contributor.authorQureshi, Nauman Khalid
dc.contributor.authorLy, Joanne
dc.contributor.authorZhang, Bingwei
dc.contributor.authorCong, Fengyu
dc.contributor.authorTang, William C.
dc.contributor.authorLiang, Zhanhua
dc.date.accessioned2020-10-20T05:46:29Z
dc.date.available2020-10-20T05:46:29Z
dc.date.issued2020
dc.identifier.citationPu, L., Qureshi, N. K., Ly, J., Zhang, B., Cong, F., Tang, W. C., & Liang, Z. (2020). Therapeutic benefits of music-based synchronous finger tapping in Parkinson’s disease : an fNIRS study protocol for randomized controlled trial in Dalian, China. <i>Trials</i>, <i>21</i>, Article 864. <a href="https://doi.org/10.1186/s13063-020-04770-9" target="_blank">https://doi.org/10.1186/s13063-020-04770-9</a>
dc.identifier.otherCONVID_42880301
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/72254
dc.description.abstractBackground Music therapy improves neuronal activity and connectivity of healthy persons and patients with clinical symptoms of neurological diseases like Parkinson’s disease, Alzheimer’s disease, and major depression. Despite the plethora of publications that have reported the positive effects of music interventions, little is known about how music improves neuronal activity and connectivity in afflicted patients. Methods For patients suffering from Parkinson’s disease (PD), we propose a daily 25-min music-based synchronous finger tapping (SFT) intervention for 8 weeks. Eligible participants with PD are split into two groups: an intervention group and a control arm. In addition, a third cohort of healthy controls will be recruited. Assessment of finger tapping performances, the Unified Parkinson’s Disease Rating Scale (UPDRS), an n-back test, the Montreal Cognitive Assessment (MoCA), as well as oxygenated hemoglobin (HbO2), deoxygenated hemoglobin (HbR), and total hemoglobin activation collected by functional near-infrared spectroscopy (fNIRS) are measured at baseline, week 4 (during), week 8 (post), and week 12 (retention) of the study. Data collected from the two PD groups are compared to baseline performances from healthy controls. Discussion This exploratory prospective trial study investigates the cortical neuronal activity and therapeutic effects associated with an auditory external cue used to induce automatic and implicit synchronous finger tapping in patients diagnosed with PD. The extent to which the intervention is effective may be dependent on the severity of the disease. The study’s findings are used to inform larger clinical studies for optimization and further exploration of the therapeutic effects of movement-based music therapy on neural activity in neurological diseases. Trial registration ClinicalTrials.gov NCT04212897. Registered on December 30, 2019. The participant recruitment and study protocol have received ethical approval from the First Affiliated Hospital of Dalian Medical University. The hospital Protocol Record number is PJ-KY-2019-123. The protocol was named “fNIRS Studies of Music Intervention of Parkinson’s Disease.” The current protocol is version 1.1, revised on September 1, 2020.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofseriesTrials
dc.rightsCC BY 4.0
dc.subject.othermusic therapy
dc.subject.otherParkinson’s disease
dc.subject.otherfNIRS
dc.subject.otherrandomized controlled trials
dc.subject.otherexplicit and implicit timing
dc.subject.othermotor-control
dc.subject.othersynchronous finger tapping
dc.titleTherapeutic benefits of music-based synchronous finger tapping in Parkinson’s disease : an fNIRS study protocol for randomized controlled trial in Dalian, China
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202010206315
dc.contributor.laitosInformaatioteknologian tiedekuntafi
dc.contributor.laitosFaculty of Information Technologyen
dc.contributor.oppiaineTietotekniikkafi
dc.contributor.oppiaineMathematical Information Technologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn1745-6215
dc.relation.volume21
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s). 2020
dc.rights.accesslevelopenAccessfi
dc.subject.ysomusiikkiterapia
dc.subject.ysoParkinsonin tauti
dc.subject.ysoneurodegeneratiiviset sairaudet
dc.subject.ysohermosolut
dc.subject.ysomusiikki
dc.subject.ysoaivokuori
dc.subject.ysohoitomenetelmät
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p16380
jyx.subject.urihttp://www.yso.fi/onto/yso/p294
jyx.subject.urihttp://www.yso.fi/onto/yso/p28721
jyx.subject.urihttp://www.yso.fi/onto/yso/p18309
jyx.subject.urihttp://www.yso.fi/onto/yso/p1808
jyx.subject.urihttp://www.yso.fi/onto/yso/p7039
jyx.subject.urihttp://www.yso.fi/onto/yso/p392
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1186/s13063-020-04770-9
jyx.fundinginformationProgram of Individualized Diagnosis and Treatment of Parkinson’s Disease and Related Dyskinesia and Construction of Neural Regulation Platform (LNCCC-C06-2015)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY 4.0
Except where otherwise noted, this item's license is described as CC BY 4.0