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dc.contributor.authorTeo, Wei‐Peng
dc.contributor.authorRantalainen, Timo
dc.contributor.authorNuzum, Nathan
dc.contributor.authorValente, Leah
dc.contributor.authorMacpherson, Helen
dc.date.accessioned2020-09-29T10:58:42Z
dc.date.available2020-09-29T10:58:42Z
dc.date.issued2021
dc.identifier.citationTeo, W., Rantalainen, T., Nuzum, N., Valente, L., & Macpherson, H. (2021). Altered prefrontal cortex responses in older adults with subjective memory complaints and dementia during dual‐task gait : an fNIRS study. <i>European Journal of Neuroscience</i>, <i>53</i>(4), 1324-1333. <a href="https://doi.org/10.1111/ejn.14989" target="_blank">https://doi.org/10.1111/ejn.14989</a>
dc.identifier.otherCONVID_42226286
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/71924
dc.description.abstractPeople with cognitive impairments show deficits during physical performances such as gait, in particular during cognitively‐challenging conditions (i.e. dual‐task gait [DTG]). However it is unclear if people at risk of dementia, such as those with subjective memory complaints (SMC), also display gait and central deficits associated with DTG. In this study, we investigated the effects of single‐ and dual‐task gait (STG and DTG), on left prefrontal cortex (PFC) activation in elderly people with subjective memory complaints (SMC) and Dementia. 58 older adults (aged 65‐94 yrs; 26 Healthy; 23 SMC; 9 Dementia) were recruited. Gait spatiotemporal characteristics (i.e. stride velocity and length) were assessed using an instrumented walkway during STG and DTG. Single‐channel functional near‐infrared spectroscopy over the left PFC was used to measure changes in oxyhaemoglobin (O2Hb) during gait. Stride velocity and length during STG (all p<0.05) and DTG (all p<0.000) were significantly impaired in people with Dementia compared to Healthy and SMC individuals. No differences were observed between Healthy and SMC. For STG, a greater increase in O2Hb (p<0.05) was observed in those with Dementia compared to the Healthy and SMC, while no differences were observed between Healthy and SMC. A significant increase and decline in O2Hb was observed during DTG in the SMC and Dementia groups respectively, compared to Healthy. Our findings indicate an altered pattern of cerebral haemodynamic response of the left PFC in DTG in people with SMC and Dementia, which may suggest that central changes precede functional impairments in people with SMC.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.relation.ispartofseriesEuropean Journal of Neuroscience
dc.rightsIn Copyright
dc.subject.otherbrain activation
dc.subject.othercognitive demands
dc.subject.otherGait kinematics
dc.subject.otherneurodegeneration
dc.subject.otherneuroimaging
dc.titleAltered prefrontal cortex responses in older adults with subjective memory complaints and dementia during dual‐task gait : an fNIRS study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202009296008
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineBiomekaniikkafi
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineBiomechanicsen
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1324-1333
dc.relation.issn0953-816X
dc.relation.numberinseries4
dc.relation.volume53
dc.type.versionacceptedVersion
dc.rights.copyright© 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
dc.rights.accesslevelopenAccessfi
dc.subject.ysodementia
dc.subject.ysoaivot
dc.subject.ysoaivokuori
dc.subject.ysokeskushermosto
dc.subject.ysokognitiiviset taidot
dc.subject.ysoliikeoppi
dc.subject.ysotoimintakyky
dc.subject.ysomuisti (kognitio)
dc.subject.ysomuistihäiriöt
dc.subject.ysokävely
dc.subject.ysoliikunta
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p1711
jyx.subject.urihttp://www.yso.fi/onto/yso/p7040
jyx.subject.urihttp://www.yso.fi/onto/yso/p7039
jyx.subject.urihttp://www.yso.fi/onto/yso/p8647
jyx.subject.urihttp://www.yso.fi/onto/yso/p24920
jyx.subject.urihttp://www.yso.fi/onto/yso/p16028
jyx.subject.urihttp://www.yso.fi/onto/yso/p10213
jyx.subject.urihttp://www.yso.fi/onto/yso/p2607
jyx.subject.urihttp://www.yso.fi/onto/yso/p2608
jyx.subject.urihttp://www.yso.fi/onto/yso/p3706
jyx.subject.urihttp://www.yso.fi/onto/yso/p916
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1111/ejn.14989
jyx.fundinginformationThis project was funded by the Alzheimer’s Australia Dementia Research Foundation (AADRF) Project Grant. HM is currently funded by an NHMRC-ARC Dementia Research Fellowship. During the conduct of this study, WPT was funded by an Alfred Deakin Postdoctoral Fellowship. The project team would like to acknowledge all participants for their time in this research.


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