Iron(III) chloride as mild catalyst for the dearomatizing cyclization of N-acylindoles
Zhang, Jingyu; Li, Jing; Ward, Jas S; Truong, Khai-Nghi; Rissanen, Kari; Albrecht, Markus (2020). Iron(III) chloride as mild catalyst for the dearomatizing cyclization of N-acylindoles. Journal of Organic Chemistry, 85 (19), 12160-12174. DOI: 10.1021/acs.joc.0c01373
Published inJournal of Organic Chemistry
Li, Jing |
© 2020 American Chemical Society
A catalytic approach for the preparation of indolines by dearomatizing cyclization is presented. FeCl3 acts as a catalyst to afford tetracyclic 5a,6-dihydro-12H-indolo[2,1-b][1,3]benzoxazin-12-ones in good yields. The cyclization also proceeds with tosylamides forming C-N bonds in 53 % yield.