Risk-Reducing Gynecological Surgery in Lynch Syndrome : Results of an International Survey from the Prospective Lynch Syndrome Database
dc.contributor.author | Dominguez-Valentin, Mev | |
dc.contributor.author | Seppälä, Toni T. | |
dc.contributor.author | Engel, Christoph | |
dc.contributor.author | Aretz, Stefan | |
dc.contributor.author | Macrae, Finlay | |
dc.contributor.author | Winship, Ingrid | |
dc.contributor.author | Capella, Gabriel | |
dc.contributor.author | Thomas, Huw | |
dc.contributor.author | Hovig, Eivind | |
dc.contributor.author | Nielsen, Maartje | |
dc.contributor.author | Sijmons, Rolf H. | |
dc.contributor.author | Bertario, Lucio | |
dc.contributor.author | Bonanni, Bernardo | |
dc.contributor.author | Tibiletti, Maria G. | |
dc.contributor.author | Cavestro, Giulia M. | |
dc.contributor.author | Mints, Miriam | |
dc.contributor.author | Gluck, Nathan | |
dc.contributor.author | Katz, Lior | |
dc.contributor.author | Heinimann, Karl | |
dc.contributor.author | Vaccaro, Carlos A. | |
dc.contributor.author | Green, Kate | |
dc.contributor.author | Lalloo, Fiona | |
dc.contributor.author | Hill, James | |
dc.contributor.author | Schmiegel, Wolff | |
dc.contributor.author | Vangala, Deepak | |
dc.contributor.author | Perne, Claudia | |
dc.contributor.author | Strauß, Hans-Georg | |
dc.contributor.author | Tecklenburg, Johanna | |
dc.contributor.author | Holinski-Feder, Elke | |
dc.contributor.author | Steinke-Lange, Verena | |
dc.contributor.author | Mecklin, Jukka-Pekka | |
dc.contributor.author | Plazzer, John-Paul | |
dc.contributor.author | Pineda, Marta | |
dc.contributor.author | Navarro, Matilde | |
dc.contributor.author | Vidal, Joan B. | |
dc.contributor.author | Kariv, Revital | |
dc.contributor.author | Rosner, Guy | |
dc.contributor.author | Piñero, Tamara A. | |
dc.contributor.author | Gonzalez, María L. | |
dc.contributor.author | Kalfayan, Pablo | |
dc.contributor.author | Sampson, Julian R. | |
dc.contributor.author | Ryan, Neil A. J. | |
dc.contributor.author | Evans, D. G. | |
dc.contributor.author | Møller, Pål | |
dc.contributor.author | Crosbie, Emma J. | |
dc.date.accessioned | 2020-08-17T12:07:45Z | |
dc.date.available | 2020-08-17T12:07:45Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Dominguez-Valentin, M., Seppälä, T. T., Engel, C., Aretz, S., Macrae, F., Winship, I., Capella, G., Thomas, H., Hovig, E., Nielsen, M., Sijmons, R. H., Bertario, L., Bonanni, B., Tibiletti, M. G., Cavestro, G. M., Mints, M., Gluck, N., Katz, L., Heinimann, K., . . . Crosbie, E. J. (2020). Risk-Reducing Gynecological Surgery in Lynch Syndrome : Results of an International Survey from the Prospective Lynch Syndrome Database. <i>Journal of Clinical Medicine</i>, <i>9</i>(7), Article 2290. <a href="https://doi.org/10.3390/jcm9072290" target="_blank">https://doi.org/10.3390/jcm9072290</a> | |
dc.identifier.other | CONVID_41725048 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/71408 | |
dc.description.abstract | Purpose: To survey risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) practice and advice regarding hormone replacement therapy (HRT) in women with Lynch syndrome. Methods: We conducted a survey in 31 contributing centers from the Prospective Lynch Syndrome Database (PLSD), which incorporates 18 countries worldwide. The survey covered local policies for risk-reducing hysterectomy and BSO in Lynch syndrome, the timing when these measures are offered, the involvement of stakeholders and advice regarding HRT. Results: Risk-reducing hysterectomy and BSO are offered to path_MLH1 and path_MSH2 carriers in 20/21 (95%) contributing centers, to path_MSH6 carriers in 19/21 (91%) and to path_PMS2 carriers in 14/21 (67%). Regarding the involvement of stakeholders, there is global agreement (~90%) that risk-reducing surgery should be offered to women, and that this discussion may involve gynecologists, genetic counselors and/or medical geneticists. Prescription of estrogen-only HRT is offered by 15/21 (71%) centers to women of variable age range (35–55 years). Conclusions: Most centers offer risk-reducing gynecological surgery to carriers of path_MLH1, path_MSH2 and path_MSH6 variants but less so for path_PMS2 carriers. There is wide variation in how, when and to whom this is offered. The Manchester International Consensus Group developed recommendations to harmonize clinical practice across centers, but there is a clear need for more research | en |
dc.format.mimetype | application/pdf | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | MDPI | |
dc.relation.ispartofseries | Journal of Clinical Medicine | |
dc.rights | CC BY 4.0 | |
dc.subject.other | Lynch syndrome | |
dc.subject.other | endometrial cancer | |
dc.subject.other | ovarian cancer | |
dc.subject.other | risk-reducing surgery | |
dc.title | Risk-Reducing Gynecological Surgery in Lynch Syndrome : Results of an International Survey from the Prospective Lynch Syndrome Database | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202008175544 | |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.relation.issn | 2077-0383 | |
dc.relation.numberinseries | 7 | |
dc.relation.volume | 9 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © 2020 the Authors | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | Lynchin oireyhtymä | |
dc.subject.yso | hormonihoito | |
dc.subject.yso | munasarjasyöpä | |
dc.subject.yso | ehkäisevä lääketiede | |
dc.subject.yso | perinnölliset taudit | |
dc.subject.yso | syöpätaudit | |
dc.subject.yso | kohdunrungon syöpä | |
dc.subject.yso | gynekologiset syövät | |
dc.subject.yso | leikkaushoito | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p23697 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p980 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p3051 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p17163 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p19997 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p678 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p12798 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p21659 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p842 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.3390/jcm9072290 | |
jyx.fundinginformation | This work was supported by the Radium Hospital Foundation (Oslo, Norway), Helse Sør-Øst (Norway), the Norwegian Cancer Society, contract 194751-2017, Finnish Cancer Foundation, Jane and Aatos Erkko Foundation, Emil Aaltonen Foundation, Finnish Medical Foundation, Sigrid Juselius Foundation, Instrumentarium Science Foundation. This work was funded by the Spanish Ministry of Science and Innovation, co-funded by FEDER funds, SAF2015-68016-R and PID2019-111254RB-I00; Instituto de Salud Carlos III CIBERONC_CB16/12/00234 and the Government of [Catalonia AGAUR_2017SGR1282, CERCA Program]. N.A.J.R was a Medical Research Council Doctoral Research Fellow (MR/M018431/1). E.J.C was a National Institute for Health Research (NIHR) Clinician Scientist (NIHR-CS-012-009), and D.G.E a NIHR Senior Investigator (NF-SI-0513-10076). D.G.E and E.J.C are supported by the all Manchester NIHR Biomedical Research Centre (IS-BRC-1215-20007). | |
dc.type.okm | A1 |
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