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dc.contributor.advisorLaukkanen, Jari
dc.contributor.advisorHeinonen, Ilkka
dc.contributor.authorGarthwaite, Taru
dc.date.accessioned2020-06-10T09:43:46Z
dc.date.available2020-06-10T09:43:46Z
dc.date.issued2020
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/69855
dc.description.abstractSedentary behavior is associated with metabolic disorders, cardiovascular disease, type 2 diabetes, and premature mortality. However, evidence regarding the health effects of sedentary behavior relies mainly on findings from observational epidemiological studies, experimental trials, or interventions of a short duration, and the understanding of causal cardiometabolic benefits of sitting time reductions in long term is lacking. The purpose of this three-month intervention study was therefore to investigate whether reducing sedentary behavior could improve the cardiometabolic health in subjects at high risk for cardiometabolic diseases. Sixty-four metabolic syndrome patients (mean age 58, standard deviation (SD) 7; 57 % women) were randomized into the intervention (n = 33) and the control group (n = 31). The intervention group was guided to limit their daily sitting time by one hour through increased standing and light physical activity, without increasing moderate-to-vigorous physical activity. The control group was guided to maintain their normal sedentary behavior and physical activity habits. At baseline and after the intervention cardiometabolic risk markers were assessed via fasting blood sample analyses and measurements of anthropometrics, body composition and blood pressure. A linear mixed model was used to estimate intervention effects and changes within groups over time, and differences between groups were tested with independent samples t-test. At three months statistically significant intervention effects in favor of the intervention group were observed in fasting insulin, insulin sensitivity, glycated hemoglobin, triglycerides, and liver enzymes alanine and aspartate aminotransferase. The intervention effects occurred mainly due to worsening of these biomarkers over time in the control group. Statistically significant favorable within-group changes in waist circumference, body fat percentage, fat free mass, blood pressure and HDL cholesterol were observed in both groups as well. However, the intervention was not effective in preventing the worsening occurring over time in fasting glucose, LDL and total cholesterol. In conclusion, an intervention aiming to reduce sedentary behavior can produce beneficial effects on cardiometabolic health in high-risk individuals by attenuating the worsening in several important risk biomarkers. Sedentary behavior reduction alone may not be strong enough stimulus to improve biomarkers, but preventing or delaying sedentary-induced worsening in risk biomarker levels in high-risk population may be an important public health implication.en
dc.format.extent65
dc.language.isoen
dc.subject.othersedentary behavior
dc.subject.othercardiometabolic health
dc.titleEffects of a sedentary behavior reduction intervention on common cardiometabolic risk factors in metabolic syndrome patients : a three-month randomized controlled trial
dc.identifier.urnURN:NBN:fi:jyu-202006104097
dc.type.ontasotMaster’s thesisen
dc.type.ontasotPro gradu -tutkielmafi
dc.contributor.tiedekuntaLiikuntatieteellinen tiedekuntafi
dc.contributor.tiedekuntaFaculty of Sport and Health Sciencesen
dc.contributor.laitosLiikunta- ja terveystieteetfi
dc.contributor.laitosSport and Health Sciencesen
dc.contributor.yliopistoJyväskylän yliopistofi
dc.contributor.yliopistoUniversity of Jyväskyläen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineSport Medicineen
dc.rights.copyrightJulkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.fi
dc.rights.copyrightThis publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.en
dc.contributor.oppiainekoodi5042
dc.subject.ysometabolinen oireyhtymä
dc.subject.ysoistuminen
dc.subject.ysometabolic syndrome
dc.subject.ysositting
dc.rights.accessrightsTekijä ei ole antanut lupaa avoimeen julkaisuun, joten aineisto on luettavissa vain Jyväskylän yliopiston kirjaston arkistotyösemalta. Ks. https://kirjasto.jyu.fi/fi/tyoskentelytilat/laitteet-ja-tilat..fi
dc.rights.accessrightsThe author has not given permission to make the work publicly available electronically. Therefore the material can be read only at the archival workstation at Jyväskylä University Library (https://kirjasto.jyu.fi/en/workspaces/facilities).en


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