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dc.contributor.authorFan, Qiao
dc.contributor.authorPozarickij, Alfred
dc.contributor.authorTan, Nicholas Y. Q.
dc.contributor.authorGuo, Xiaobo
dc.contributor.authorVerhoeven, Virginie J. M.
dc.contributor.authorVitart, Veronique
dc.contributor.authorGuggenheim, Jeremy A.
dc.contributor.authorMiyake, Masahiro
dc.contributor.authorTideman, J. Willem L.
dc.contributor.authorKhawaja, Anthony P.
dc.contributor.authorZhang, Liang
dc.contributor.authorMacGregor, Stuart
dc.contributor.authorHöhn, René
dc.contributor.authorChen, Peng
dc.contributor.authorBiino, Ginevra
dc.contributor.authorWedenoja, Juho
dc.contributor.authorSaffari, Seyed Ehsan
dc.contributor.authorTedja, Milly S.
dc.contributor.authorXie, Jing
dc.contributor.authorLanca, Carla
dc.contributor.authorWang, Ya Xing
dc.contributor.authorSahebjada, Srujana
dc.contributor.authorMazur, Johanna
dc.contributor.authorMirshahi, Alireza
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorYazar, Seyhan
dc.contributor.authorPennell, Craig E.
dc.contributor.authorYap, Maurice
dc.contributor.authorHaarman, Annechien E. G.
dc.contributor.authorEnthoven, Clair A.
dc.contributor.authorPolling, JanRoelof
dc.contributor.authorBailey-Wilson, Joan E.
dc.contributor.authorVeluchamy, Amutha Barathi
dc.contributor.authorBurdon, Kathryn P.
dc.contributor.authorCampbell, Harry
dc.contributor.authorChen, Li Jia
dc.contributor.authorChew, Emily Y.
dc.contributor.authorCraig, Jamie E.
dc.contributor.authorCumberland, Phillippa M.
dc.contributor.authorDeangelis, Margaret M.
dc.contributor.authorDelcourt, Cécile
dc.contributor.authorDing, Xiaohu
dc.contributor.authorEvans, David M.
dc.contributor.authorGharahkhani, Puya
dc.contributor.authorIglesias, Adriana I.
dc.contributor.authorHaller, Toomas
dc.contributor.authorHan, Xikun
dc.contributor.authorHoang, Quan
dc.contributor.authorIgo, Robert P.
dc.contributor.authorIyengar, Sudha K.
dc.contributor.authorKähönen, Mika
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorKlein, Barbara E.
dc.contributor.authorKlein, Ronald
dc.contributor.authorLass, Jonathan H.
dc.contributor.authorLee, Kris
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorLewis, Deyana D.
dc.contributor.authorLi, Qing
dc.contributor.authorLi, Shi-Ming
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorMeguro, Akira
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMiddlebrooks, Candace D.
dc.contributor.authorMizuki, Nobuhisa
dc.contributor.authorMusolf, Anthony M.
dc.contributor.authorNickels, Stefan
dc.contributor.authorOexle, Konrad
dc.contributor.authorPang, Chi Pui
dc.contributor.authorPaterson, Andrew D.
dc.contributor.authorRahi, Jugnoo S.
dc.contributor.authorRaitakari, Olli
dc.contributor.authorRudan, Igor
dc.contributor.authorStambolian, Dwight
dc.contributor.authorSimpson, Claire L.
dc.contributor.authorWang, Ningli
dc.contributor.authorBin Wei, Wen
dc.contributor.authorWilliams, Katie M.
dc.contributor.authorWilson, James F.
dc.contributor.authorWojciechowski, Robert
dc.contributor.authorYamashiro, Kenji
dc.contributor.authorYam, Jason C. S.
dc.contributor.authorZhou, Xiangtian
dc.contributor.authorAslam, Tariq
dc.contributor.authorBarman, Sarah A.
dc.contributor.authorBarrett, Jenny H.
dc.contributor.authorBishop, Paul
dc.contributor.authorBlows, Peter
dc.contributor.authorBunce, Catey
dc.contributor.authorCarare, Roxana O.
dc.contributor.authorChakravarthy, Usha
dc.contributor.authorChan, Michelle
dc.contributor.authorChua, Sharon Y. L.
dc.contributor.authorCrabb, David P.
dc.contributor.authorCumberland, Philippa M.
dc.contributor.authorDay, Alexander
dc.contributor.authorDesai, Parul
dc.contributor.authorDhillon, Bal
dc.contributor.authorDick, Andrew D.
dc.contributor.authorEgan, Cathy
dc.contributor.authorEnnis, Sarah
dc.contributor.authorFruttiger, Marcus
dc.contributor.authorGallacher, John E. J.
dc.contributor.authorGarway-Heath, David F.
dc.contributor.authorGibson, Jane
dc.contributor.authorGore, Dan
dc.contributor.authorHardcastle, Alison
dc.contributor.authorHarding, Simon P.
dc.contributor.authorHogg, Ruth E.
dc.contributor.authorKeane, Pearse A.
dc.contributor.authorKhaw, Sir Peng T.
dc.contributor.authorLascaratos, Gerassimos
dc.contributor.authorLotery, Andrew J.
dc.contributor.authorMacgillivray, Tom
dc.contributor.authorMackie, Sarah
dc.contributor.authorMartin, Keith
dc.contributor.authorMcGaughey, Michelle
dc.contributor.authorMcGuinness, Bernadette
dc.contributor.authorMcKay, Gareth J.
dc.contributor.authorMcKibbin, Martin
dc.contributor.authorMitry, Danny
dc.contributor.authorMoore, Tony
dc.contributor.authorMorgan, James E.
dc.contributor.authorMuthy, Zaynah A.
dc.contributor.authorO’Sullivan, Eoin
dc.contributor.authorOwen, Chris G.
dc.contributor.authorPatel, Praveen
dc.contributor.authorPaterson, Euan
dc.contributor.authorPeto, Tunde
dc.contributor.authorPetzold, Axel
dc.contributor.authorRahi, Jugnoo S.
dc.contributor.authorRudnikca, Alicja R.
dc.contributor.authorSelf, Jay
dc.contributor.authorSivaprasad, Sobha
dc.contributor.authorSteel, David
dc.contributor.authorStratton, Irene
dc.contributor.authorStrouthidis, Nicholas
dc.contributor.authorSudlow, Cathie
dc.contributor.authorThomas, Dhanes
dc.contributor.authorTrucco, Emanuele
dc.contributor.authorTufail, Adnan
dc.contributor.authorVernon, Stephen A.
dc.contributor.authorViswanathan, Ananth C.
dc.contributor.authorWilliams, Katie
dc.contributor.authorWoodside, Jayne V.
dc.contributor.authorYates, Max M.
dc.contributor.authorYip, Jennifer
dc.contributor.authorZheng, Yalin
dc.contributor.authorHewitt, Alex W.
dc.contributor.authorJaddoe, Vincent W. V.
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorHayward, Caroline
dc.contributor.authorPolasek, Ozren
dc.contributor.authorTai, E-Shyong
dc.contributor.authorYoshikatsu, Hosoda
dc.contributor.authorHysi, Pirro G.
dc.contributor.authorYoung, Terri L.
dc.contributor.authorTsujikawa, Akitaka
dc.contributor.authorWang, Jie Jing
dc.contributor.authorMitchell, Paul
dc.contributor.authorPfeiffer, Norbert
dc.contributor.authorPärssinen, Olavi
dc.contributor.authorFoster, Paul J.
dc.contributor.authorFossarello, Maurizio
dc.contributor.authorYip, Shea Ping
dc.contributor.authorWilliams, Cathy
dc.contributor.authorHammond, Christopher J.
dc.contributor.authorJonas, Jost B.
dc.contributor.authorHe, Mingguang
dc.contributor.authorMackey, David A.
dc.contributor.authorWong, Tien-Yin
dc.contributor.authorKlaver, Caroline C. W.
dc.contributor.authorSaw, Seang-Mei
dc.contributor.authorBaird, Paul N.
dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorConsortium for Refractive Error and Myopia (CREAM)
dc.contributor.authorUK Biobank Eye and Vision Consortium
dc.date.accessioned2020-03-31T04:04:09Z
dc.date.available2020-03-31T04:04:09Z
dc.date.issued2020
dc.identifier.citationFan, Qiao; Pozarickij, Alfred; Tan, Nicholas Y. Q.; Guo, Xiaobo; Verhoeven, Virginie J. M.; Vitart, Veronique; Guggenheim, Jeremy A.; Miyake, Masahiro; Tideman, J. Willem L.; Khawaja, Anthony P. et al. (2020). Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error. Communications Biology, 3, 133. DOI: 10.1038/s42003-020-0802-y
dc.identifier.otherCONVID_35138078
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/68379
dc.description.abstractCorneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature GWAS in 44,042 individuals of Caucasian and Asian with replication in 88,218 UK Biobank data. We identified 47 loci (of which 26 are novel), with population-specific signals as well as shared signals across ethnicities. Some identified variants showed precise scaling in corneal curvature and eye elongation (i.e. axial length) to maintain eyes in emmetropia (i.e. HDAC11/FBLN2 rs2630445, RBP3 rs11204213); others exhibited association with myopia with little pleiotropic effects on eye elongation. Implicated genes are involved in extracellular matrix organization, developmental process for body and eye, connective tissue cartilage and glycosylation protein activities. Our study provides insights into population-specific novel genes for corneal curvature, and their pleiotropic effect in regulating eye size or conferring susceptibility to myopia.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesCommunications Biology
dc.rightsCC BY 4.0
dc.titleGenome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202003312593
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn2399-3642
dc.relation.volume3
dc.type.versionpublishedVersion
dc.rights.copyright© The Authors, 2020
dc.rights.accesslevelopenAccessfi
dc.subject.ysogeneettiset tekijät
dc.subject.ysolikinäköisyys
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p21661
jyx.subject.urihttp://www.yso.fi/onto/yso/p5995
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s42003-020-0802-y


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