dc.contributor.author | Alén, Markku | |
dc.date.accessioned | 2020-02-28T09:18:51Z | |
dc.date.available | 2020-02-28T09:18:51Z | |
dc.date.issued | 1985 | |
dc.identifier.isbn | 978-951-39-7899-0 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/67999 | |
dc.description.abstract | Eleven top-level power athletes (6 control, 5 experimental subjects) completed the prospective 42 weeks of investigation aimed to elucidate androgenic-anabolic steroid effects on endocrinology and metabolism. During the first 26 weeks of strength training the experimental subjects self-administered testosterone and anabolic steroids in doses which exceeded the therapeutic dose by 5 to 12 times. After 26 weeks serum testosterone had increased 2. 3-fold. This was associated with a 7-fold increase in serum estradiol, leading to gynecomastia, and significant decreases in serum FSH and LH. Testicular function was impaired, as seen from both the low serum testosterone (9±8 nmol/1) immediately following drug withdrawal and azoospermia, and decreased testicular volume. Significantly decreased serum HDL and HDL₂ -cholesterol were detected, but total cholesterol was not affected. Serum ALAT, AFOS, γ-GT and total bilirubin remained within reference interval. A return towards the initial values was observed in the course of 12-16 weeks following drug withdrawal in the variables affected, indicating long-lasting impairment of testicular function and suggesting increased risk of later development of atherosclerosis. In the control group there were only insignificant fluctuations in the variables registered, except for a significant increase in serum LH after 26 weeks' training. | en |
dc.relation.ispartofseries | Studies in Sport, Physical Education and Health | |
dc.rights | In Copyright | |
dc.subject | anabolic steroids | |
dc.subject | cholesterol | |
dc.subject | enzymes | |
dc.subject | lipids | |
dc.subject | spermatogenesis | |
dc.subject | testosterone | |
dc.subject | anaboliset steroidit | |
dc.subject | doping | |
dc.subject | entsyymit | |
dc.subject | hormonit | |
dc.subject | kolesteroli | |
dc.subject | lipidit | |
dc.subject | lääkeaineet | |
dc.subject | sukupuolihormonit | |
dc.title | Effects of self-administered, high-dose testosterone and anabolic steroids on serum hormones, lipids, entzymes and on spermatogenesis in power athletes | |
dc.type | Diss. | |
dc.identifier.urn | URN:ISBN:978-951-39-7899-0 | |
dc.rights.accesslevel | openAccess | |
dc.rights.url | https://rightsstatements.org/page/InC/1.0/ | |
dc.date.digitised | 2019 | |