Overweight and obesity are associated with cardiac adverse structure remodeling in Chinese elderly with hypertension
Liu, C., Li, G., Laukkanen, J. A., Hao, L., Zhao, Q., Zhang, J., & Zhang, X. (2019). Overweight and obesity are associated with cardiac adverse structure remodeling in Chinese elderly with hypertension. Scientific Reports, 9, Article 17896. https://doi.org/10.1038/s41598-019-54359-9
Published inScientific Reports
Li, Gang |
Hao, Lan |
© The Author(s) 2019
There is limited information on the association of overweight and obesity with cardiac remodeling in elderly population. Therefore, we investigated whether overweight and obesity are associated with cardiac geometric structures and function in Chinese elderly. A total of 1183 hospitalized patients (aged 65–99 years) with primary hypertension were collected retrospectively in a cross-sectional study, and divided into underweight, normal weight, overweight and obesity patient groups according to their body mass index (BMI). Cardiac echocardiographic parameters were compared between the groups. BMI was 17.2 ± 1.2, 21.4 ± 1.2, 25.1 ± 1.2, 30.2 ± 2.6 kg/m2 in underweight, normal weight, overweight and obesity groups respectively. Aortic and left atrial diameter, interventricular septal and left ventricular (LV) posterior wall thickness, LV end-diastolic and end-systolic diameter, and indexed LV mass, and prevalence of E/A reversal were higher, while LV ejection fraction and fractional shortening were lower in elderly with overweight or obesity, as compared with whose with underweight or normal weight separately (All P < 0.05). However, multivariable regression analysis showed that overweight and obesity are independently related to increased LV wall thickness, end-diastolic diameter and mass (All P < 0.05). In conclusions, this study demonstrates that overweight and obesity are associated with increased LV wall thickness, end-diastolic diameter and mass in Asian elderly. ...
PublisherNature Publishing Group
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Additional information about fundingThis study was supported by the natural science research fund of Chongqing Science & Technology Commission in Chongqing City, China (CSTC, No. 2007BB5276), the medical science & technology research fund of Health Bureau of Chongqing City, China (No. 04-2-154 and No. 2009-2-290) and the grant from National Key Clinical Specialties Construction Program of China (No. 544).
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