Changing environmental influences on substance use across development
Dick, D., Pagan, J., Viken, R., Purcell, S., Kaprio, J., Pulkkinen, L., & Rose, R. (2007). Changing environmental influences on substance use across development. Twin Research and Human Genetics, 10 (2), 315-326. https://doi.org/10.1375/twin.10.2.315
Published inTwin Research and Human Genetics
© Cambridge University Press 2007
In contrast to many phenotypes that have been studied using twin designs, substance use shows considerable evidence of environmental influence. Accordingly, specifying the relevant environments and understanding the nature of their effects is an important research priority. Twin studies also have demonstrated that the importance of genetic and environmental influences varies across development for a variety of behavioral outcomes, including substance use. Here, we report analyses exploring moderating effects associated with parenting and peer characteristics on adolescent smoking and drinking, measured at ages 14 and 17. We find significant evidence of moderating effects associated with two dimensions of parenting (parental monitoring and time spent in activities with parents) on adolescent smoking, measured at two time points across development, but no moderating effects on adolescent drinking. Genetic influences on smoking increased, and common environmental effects decreased, as adolescents reported less parental monitoring and spending more time with their parents. Conversely, we find evidence that adolescent drinking is more strongly influenced by peer characteristics. The importance of genetic predispositions was increased among adolescents who reported more friends who used alcohol. These analyses illustrate the importance of incorporating measured aspects of the environment into genetically informative twin models to begin to understand how specific environments are related to various outcomes. Furthermore, they illustrate the importance of using a developmental perspective to understand how specific influences may vary across different ages, and across different phenotypes. ...
MetadataShow full item record
Showing items with similar title or keywords.
Genetic and environmental influences underlying externalizing behaviors, cigarette smoking and illicit drug use across adolescence Korhonen, T.; Latvala, A.; Dick, D.M.; Pulkkinen, Lea; Rose, R.J.; Kaprio, J.; Huizink, A.C. (Springer, 2012)We investigated genetic and environmental influences common to adolescent externalizing behavior (at age 12), smoking (at age 14) and initiation of drug use (at age 17) using the FinnTwin12 cohort data. Multivariate Cholesky ...
Cleanliness, order and beauty are central values influencing the acceptance of biodiverse lawns across Europe - a cross-continental interview study Lampinen, Jussi; Tuomi, Maria (Open Science Centre, University of Jyväskylä, 2018)Regularly managed lawns are emblematic features of urban green spaces. They provide utility and aesthetic values, but often exhibit low species-richness and high management costs. Management interventions that convert such ...
Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error Fan, Qiao; Pozarickij, Alfred; Tan, Nicholas Y. Q.; Guo, Xiaobo; Verhoeven, Virginie J. M.; Vitart, Veronique; Guggenheim, Jeremy A.; Miyake, Masahiro; Tideman, J. Willem L.; Khawaja, Anthony P.; Zhang, Liang; MacGregor, Stuart; Höhn, René; Chen, Peng; Biino, Ginevra; Wedenoja, Juho; Saffari, Seyed Ehsan; Tedja, Milly S.; Xie, Jing; Lanca, Carla; Wang, Ya Xing; Sahebjada, Srujana; Mazur, Johanna; Mirshahi, Alireza; Martin, Nicholas G.; Yazar, Seyhan; Pennell, Craig E.; Yap, Maurice; Haarman, Annechien E. G.; Enthoven, Clair A.; Polling, JanRoelof; Bailey-Wilson, Joan E.; Veluchamy, Amutha Barathi; Burdon, Kathryn P.; Campbell, Harry; Chen, Li Jia; Chew, Emily Y.; Craig, Jamie E.; Cumberland, Phillippa M.; Deangelis, Margaret M.; Delcourt, Cécile; Ding, Xiaohu; Evans, David M.; Gharahkhani, Puya; Iglesias, Adriana I.; Haller, Toomas; Han, Xikun; Hoang, Quan; Igo, Robert P.; Iyengar, Sudha K.; Kähönen, Mika; Kaprio, Jaakko; Klein, Barbara E.; Klein, Ronald; Lass, Jonathan H.; Lee, Kris; Lehtimäki, Terho; Lewis, Deyana D.; Li, Qing; Li, Shi-Ming; Lyytikäinen, Leo-Pekka; Meguro, Akira; Metspalu, Andres; Middlebrooks, Candace D.; Mizuki, Nobuhisa; Musolf, Anthony M.; Nickels, Stefan; Oexle, Konrad; Pang, Chi Pui; Paterson, Andrew D.; Rahi, Jugnoo S.; Raitakari, Olli; Rudan, Igor; Stambolian, Dwight; Simpson, Claire L.; Wang, Ningli; Bin Wei, Wen; Williams, Katie M.; Wilson, James F.; Wojciechowski, Robert; Yamashiro, Kenji; Yam, Jason C. S.; Zhou, Xiangtian; Aslam, Tariq; Barman, Sarah A.; Barrett, Jenny H.; Bishop, Paul; Blows, Peter; Bunce, Catey; Carare, Roxana O.; Chakravarthy, Usha; Chan, Michelle; Chua, Sharon Y. L.; Crabb, David P.; Cumberland, Philippa M.; Day, Alexander; Desai, Parul; Dhillon, Bal; Dick, Andrew D.; Egan, Cathy; Ennis, Sarah; Fruttiger, Marcus; Gallacher, John E. J.; Garway-Heath, David F.; Gibson, Jane; Gore, Dan; Hardcastle, Alison; Harding, Simon P.; Hogg, Ruth E.; Keane, Pearse A.; Khaw, Sir Peng T.; Lascaratos, Gerassimos; Lotery, Andrew J.; Macgillivray, Tom; Mackie, Sarah; Martin, Keith; McGaughey, Michelle; McGuinness, Bernadette; McKay, Gareth J.; McKibbin, Martin; Mitry, Danny; Moore, Tony; Morgan, James E.; Muthy, Zaynah A.; O’Sullivan, Eoin; Owen, Chris G.; Patel, Praveen; Paterson, Euan; Peto, Tunde; Petzold, Axel; Rahi, Jugnoo S.; Rudnikca, Alicja R.; Self, Jay; Sivaprasad, Sobha; Steel, David; Stratton, Irene; Strouthidis, Nicholas; Sudlow, Cathie; Thomas, Dhanes; Trucco, Emanuele; Tufail, Adnan; Vernon, Stephen A.; Viswanathan, Ananth C.; Williams, Katie; Woodside, Jayne V.; Yates, Max M.; Yip, Jennifer; Zheng, Yalin; Hewitt, Alex W.; Jaddoe, Vincent W. V.; van Duijn, Cornelia M.; Hayward, Caroline; Polasek, Ozren; Tai, E-Shyong; Yoshikatsu, Hosoda; Hysi, Pirro G.; Young, Terri L.; Tsujikawa, Akitaka; Wang, Jie Jing; Mitchell, Paul; Pfeiffer, Norbert; Pärssinen, Olavi; Foster, Paul J.; Fossarello, Maurizio; Yip, Shea Ping; Williams, Cathy; Hammond, Christopher J.; Jonas, Jost B.; He, Mingguang; Mackey, David A.; Wong, Tien-Yin; Klaver, Caroline C. W.; Saw, Seang-Mei; Baird, Paul N.; Cheng, Ching-Yu; Consortium for Refractive Error and Myopia (CREAM); UK Biobank Eye and Vision Consortium (Nature Publishing Group, 2020)Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature ...
Environmental drivers of canopy gap geometry: a meta-analysis of gap disturbance regimes across forest biomes Fujinuma, Junichi; Aakala, Tuomas; Kusumoto, Buntarou; Kuuluvainen, Timo; Kubota, Yasuhiro (Open Science Centre, University of Jyväskylä, 2018)Forest degradation and related biodiversity loss require urgent improvement of forest management practices. Ecological forestry, including emulation of natural disturbances and retention management is considered a promising ...
Depressive symptoms and alcohol use are genetically and environmentally correlated across adolescence Edwards, Alexis; Sihvola, Elina; Korhonen, Tellervo; Pulkkinen, Lea; Moilanen, Irma; Kaprio, Jaakko; Rose, Richard J.; Dick, Danielle M. (Springer New York LLC, 2011)Depressive symptoms and alcohol use are frequently positively associated during adolescence. This study aimed to assess the heritability of each phenotype across adolescence; to assess potential shared liabilities; to ...