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dc.contributor.authorAssoah, Benedicta
dc.contributor.authorRiihonen, Vesa
dc.contributor.authorVale, João R.
dc.contributor.authorValkonen, Arto
dc.contributor.authorCandeias, Nuno R.
dc.date.accessioned2019-07-25T07:21:17Z
dc.date.available2019-07-25T07:21:17Z
dc.date.issued2019
dc.identifier.citationAssoah, Benedicta; Riihonen, Vesa; Vale, João R.; Valkonen, Arto; Candeias, Nuno R. (2019). Synthesis of 6,12-Disubstituted Methanodibenzo[b,f][1,5]dioxocins : Pyrrolidine Catalyzed Self-Condensation of 2′-Hydroxyacetophenones. Molecules, 24 (13), 2405. DOI: 10.3390/molecules24132405
dc.identifier.otherCONVID_32133489
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65113
dc.description.abstractThe preparation of unprecedented 6,12-disubstituted methanodibenzo[b,f][1,5]dioxocins from pyrrolidine catalyzed self-condensation of 2′-hydroxyacetophenones is herein described. This method provides easy access to this highly bridged complex core, resulting in construction of two C–O and two C–C bonds, a methylene bridge and two quaternary centers in a single step. The intricate methanodibenzo[b,f][1,5]dioxocin compounds were obtained in up to moderate yields after optimization of the reaction conditions concerning solvent, reaction times and the use of additives. Several halide substituted methanodibenzo[b,f][1,5]dioxocins could be prepared from correspondent 2′-hydroxyacetophenones.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.relation.ispartofseriesMolecules
dc.rightsCC BY 4.0
dc.subject.otherenamine
dc.subject.other1,5-dioxocin
dc.subject.otherself-condensation
dc.subject.other2′-hydroxyacetophenone
dc.titleSynthesis of 6,12-Disubstituted Methanodibenzo[b,f][1,5]dioxocins : Pyrrolidine Catalyzed Self-Condensation of 2′-Hydroxyacetophenones
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201907253675
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn1420-3049
dc.relation.numberinseries13
dc.relation.volume24
dc.type.versionpublishedVersion
dc.rights.copyright© 2019 by the authors.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber314343
dc.subject.ysoorgaaniset yhdisteet
dc.subject.ysokemiallinen synteesi
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p3841
jyx.subject.urihttp://www.yso.fi/onto/yso/p8468
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/molecules24132405
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundinginformationThis research was funded by Academy of Finland, grant numbers 326487, 326486 and 314343. The APC was funded by 326486.


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