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dc.contributor.authorMäntynen, Sari
dc.contributor.authorSundberg, Lotta-Riina
dc.contributor.authorOksanen, Hanna M.
dc.contributor.authorPoranen, Minna M.
dc.date.accessioned2019-01-22T10:38:20Z
dc.date.available2019-01-22T10:38:20Z
dc.date.issued2019
dc.identifier.citationMäntynen, S., Sundberg, L.-R., Oksanen, H. M., & Poranen, M. M. (2019). Half a Century of Research on Membrane-Containing Bacteriophages: Bringing New Concepts to Modern Virology. <i>Viruses</i>, <i>11</i>(1), Article 76. <a href="https://doi.org/10.3390/v11010076" target="_blank">https://doi.org/10.3390/v11010076</a>
dc.identifier.otherCONVID_28876123
dc.identifier.otherTUTKAID_80404
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/62582
dc.description.abstractHalf a century of research on membrane-containing phages has had a major impact on virology, providing new insights into virus diversity, evolution and ecological importance. The recent revolutionary technical advances in imaging, sequencing and lipid analysis have significantly boosted the depth and volume of knowledge on these viruses. This has resulted in new concepts of virus assembly, understanding of virion stability and dynamics, and the description of novel processes for viral genome packaging and membrane-driven genome delivery to the host. The detailed analyses of such processes have given novel insights into DNA transport across the protein-rich lipid bilayer and the transformation of spherical membrane structures into tubular nanotubes, resulting in the description of unexpectedly dynamic functions of the membrane structures. Membrane-containing phages have provided a framework for understanding virus evolution. The original observation on membrane-containing bacteriophage PRD1 and human pathogenic adenovirus has been fundamental in delineating the concept of “viral lineages”, postulating that the fold of the major capsid protein can be used as an evolutionary fingerprint to trace long-distance evolutionary relationships that are unrecognizable from the primary sequences. This has brought the early evolutionary paths of certain eukaryotic, bacterial, and archaeal viruses together, and potentially enables the reorganization of the nearly immeasurable virus population (~1 × 1031) on Earth into a reasonably low number of groups representing different architectural principles. In addition, the research on membrane-containing phages can support the development of novel tools and strategies for human therapy and crop protection.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.ispartofseriesViruses
dc.rightsCC BY 4.0
dc.subject.othertectiviridae
dc.subject.othercystoviridae
dc.subject.othercorticoviridae
dc.subject.otherplasmaviridae
dc.subject.otherlipid-containing bacteriophage
dc.subject.othervirus-host interaction
dc.subject.othervirus evolution
dc.titleHalf a Century of Research on Membrane-Containing Bacteriophages: Bringing New Concepts to Modern Virology
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201901181244
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineBiologisten vuorovaikutusten huippututkimusyksikköfi
dc.contributor.oppiaineNanoscience Centerfi
dc.contributor.oppiaineCell and Molecular Biologyen
dc.contributor.oppiaineCentre of Excellence in Biological Interactions Researchen
dc.contributor.oppiaineNanoscience Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-01-18T13:15:13Z
dc.type.coarhttp://purl.org/coar/resource_type/c_dcae04bc
dc.description.reviewstatuspeerReviewed
dc.relation.issn1999-4915
dc.relation.numberinseries1
dc.relation.volume11
dc.type.versionpublishedVersion
dc.rights.copyrightthe Authors, 2019.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber314939
dc.relation.grantnumber266879
dc.subject.ysovirukset
dc.subject.ysobakteriofagit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p1123
jyx.subject.urihttp://www.yso.fi/onto/yso/p25303
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/v11010076
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundinginformation: This work was funded by the Finnish Centre of Excellence Program of the Academy of Finland; the CoE in Biological Interactions 2012–2017 (#252411), Academy of Finland grants #266879 and #314939 (L.-R.S.), and the Jane and Aatos Erkko Foundation and the Sigrid Juselius Foundation (M.M.P.). H.M.O. was supported by funding for Instruct-FI (Instruct-HiLIFE and Biocenter Finland).
dc.type.okmA2


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