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dc.contributor.authorYaouba, Souaibou
dc.contributor.authorValkonen, Arto
dc.contributor.authorCoghi, Paolo
dc.contributor.authorGao, Jiaying
dc.contributor.authorGuantai, Eric M.
dc.contributor.authorDerese, Solomon
dc.contributor.authorWong, Vincent K. W.
dc.contributor.authorErdélyi, Máté
dc.contributor.authorYenesew, Abiy
dc.date.accessioned2018-12-14T12:42:20Z
dc.date.available2018-12-14T12:42:20Z
dc.date.issued2018
dc.identifier.citationYaouba, S., Valkonen, A., Coghi, P., Gao, J., Guantai, E. M., Derese, S., Wong, V. K. W., Erdélyi, M., & Yenesew, A. (2018). Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species. <i>Molecules</i>, <i>23</i>(12), Article 3199. <a href="https://doi.org/10.3390/molecules23123199" target="_blank">https://doi.org/10.3390/molecules23123199</a>
dc.identifier.otherCONVID_28786477
dc.identifier.otherTUTKAID_79893
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/60617
dc.description.abstractA phytochemical investigation of the roots of Aspilia plurisetaled to the isolation of ent-kaurane-type diterpenoids and additional phytochemicals (1⁻23). The structures of the isolated compounds were elucidated based on Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analyses. The absolute configurations of seven of the ent-kaurane-type diterpenoids (3⁻6, 6b, 7 and 8) were determined by single crystal X-ray diffraction studies. Eleven of the compounds were also isolated from the roots and the aerial parts of Aspilia mossambicensis. The literature NMR assignments for compounds 1 and 5 were revised. In a cytotoxicity assay, 12α-methoxy-ent-kaur-9(11),16-dien-19-oic acid (1) (IC50 = 27.3 ± 1.9 µM) and 9β-hydroxy-15α-angeloyloxy-ent-kaur-16-en-19-oic acid (3) (IC50 = 24.7 ± 2.8 µM) were the most cytotoxic against the hepatocellular carcinoma (Hep-G2) cell line, while 15α-angeloyloxy-16β,17-epoxy-ent-kauran-19-oic acid (5) (IC50 = 30.7 ± 1.7 µM) was the most cytotoxic against adenocarcinomic human alveolar basal epithelial (A549) cells.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesMolecules
dc.rightsCC BY 4.0
dc.subject.otherAspilia mossambicensis
dc.subject.otherAspilia pluriseta
dc.subject.otherAsteraceae
dc.subject.otherX-ray crystal structure
dc.subject.othercytotoxicity
dc.subject.otherent-kaurane diterpenoid.
dc.titleCrystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201812145129
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemiafi
dc.contributor.oppiaineOrganic Chemistryen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-12-14T10:15:20Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn1420-3049
dc.relation.numberinseries12
dc.relation.volume23
dc.type.versionpublishedVersion
dc.rights.copyright© the Authors, 2018.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber314343
dc.subject.ysoluonnonaineet
dc.subject.ysoterpeenit
dc.subject.ysoröntgenkristallografia
dc.subject.ysoasterikasvit
dc.subject.ysosolunsalpaajat
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p6956
jyx.subject.urihttp://www.yso.fi/onto/yso/p12115
jyx.subject.urihttp://www.yso.fi/onto/yso/p29058
jyx.subject.urihttp://www.yso.fi/onto/yso/p3759
jyx.subject.urihttp://www.yso.fi/onto/yso/p9995
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/molecules23123199
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundinginformationS.Y. acknowledges the support of the AFIMEGQ intra-ACP project for a fellowship. A.V. kindly acknowledges the Academy of Finland (grant no. 314343) for financial support. Funding was also provided by the Swedish Research Council (2016-05857) and the International Science Program (ISP Sweden, grant KEN-02). Patrick B. Chalo Mutiso, School of Biological Sciences, University of Nairobi, Kenya, is acknowledged for the identification of the plant material. V.K.W.W. acknowledges the Macao Science and Technology Development Fund for financial support (FDTC grant Project code: 0022/2018/A1).


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