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dc.contributor.authorJackson, Victoria E.
dc.contributor.authorLatourelle, Jeanne C.
dc.contributor.authorWain, Louise V.
dc.contributor.authorSmith, Albert V.
dc.contributor.authorGrove, Megan L.
dc.contributor.authorBartz, Traci M.
dc.contributor.authorObeidat, Ma'en
dc.contributor.authorProvince, Michael A.
dc.contributor.authorGao, Wei
dc.contributor.authorQaiser, Beenish
dc.contributor.authorPorteous, David J.
dc.contributor.authorCassano, Patricia A.
dc.contributor.authorAhluwalia, Tarunveer S.
dc.contributor.authorGrarup, Niels
dc.contributor.authorLi, Jin
dc.contributor.authorAltmaier, Elisabeth
dc.contributor.authorMarten, Jonathan
dc.contributor.authorHarris, Sarah E.
dc.contributor.authorManichaikul, Ani
dc.contributor.authorPottinger, Tess D.
dc.contributor.authorLi-Gao, Ruifang
dc.contributor.authorLind-Thomsen, Allan
dc.contributor.authorMahajan, Anubha
dc.contributor.authorLahousse, Lies
dc.contributor.authorImboden, Medea
dc.contributor.authorTeumer, Alexander
dc.contributor.authorPrins, Bram
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorFranceschini, Nora
dc.contributor.authorSitlani, Colleen M.
dc.contributor.authorBrody, Jennifer A.
dc.contributor.authorBossé, Yohan
dc.contributor.authorTimens, Wim
dc.contributor.authorKraja, Aldi
dc.contributor.authorLoukola, Anu
dc.contributor.authorTang, Wenbo
dc.contributor.authorLiu, Yongmei
dc.contributor.authorBork-Jensen, Jette
dc.contributor.authorJustesen, Johanne M.
dc.contributor.authorLinneberg, Allan
dc.contributor.authorLange, Leslie A.
dc.contributor.authorRawal, Rajesh
dc.contributor.authorKarrasch, Stefan
dc.contributor.authorHuffman, Jennifer E.
dc.contributor.authorSmith, Blair H.
dc.contributor.authorDavies, Gail
dc.contributor.authorBurkart, Kristin M.
dc.contributor.authorMychaleckyj, Josyf C.
dc.contributor.authorBonten, Tobias N.
dc.contributor.authorEnroth, Stefan
dc.contributor.authorLind, Lars
dc.contributor.authorBrusselle, Guy G.
dc.contributor.authorKumar, Ashish
dc.contributor.authorStubbe, Beate
dc.contributor.authorKähönen, Mika
dc.contributor.authorWyss, Annah B.
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorHeckbert, Susan R.
dc.contributor.authorHao, Ke
dc.contributor.authorRantanen, Taina
dc.contributor.authorKritchevsky, Stephen B.
dc.contributor.authorLohman, Kurt
dc.contributor.authorSkaaby, Tea
dc.contributor.authorPisinger, Charlotta
dc.contributor.authorHansen, Torben
dc.contributor.authorSchulz, Holger
dc.contributor.authorPolasek, Ozren
dc.contributor.authorCampbell, Archie
dc.contributor.authorStarr, John M.
dc.contributor.authorRich, Stephen S.
dc.contributor.authorMook-Kanamori, Dennis O.
dc.contributor.authorJohansson, Åsa
dc.contributor.authorIngelsson, Erik
dc.contributor.authorUitterlinden, André G.
dc.contributor.authorWeiss, Stefan
dc.contributor.authorRaitakari, Olli T.
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorNorth, Kari E.
dc.contributor.authorGharib, Sina A.
dc.contributor.authorSin, Don D.
dc.contributor.authorTaylor, Kent D.
dc.contributor.authorO'Connor, George T.
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorPederson, Oluf
dc.contributor.authorVestergaard, Henrik
dc.contributor.authorWilson, James G.
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorHayward, Caroline
dc.contributor.authorKerr, Shona
dc.contributor.authorDeary, Ian J.
dc.contributor.authorBarr, R. Graham
dc.contributor.authorMutsert, Renée de
dc.contributor.authorGyllensten, Ulf
dc.contributor.authorMorris, Andrew P.
dc.contributor.authorIkram, M. Arfan
dc.contributor.authorProbst-Hensch, Nicole
dc.contributor.authorGläser, Sven
dc.contributor.authorZeggini, Eleftheria
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorStrachan, David P.
dc.contributor.authorDupuis, Josée
dc.contributor.authorMorrison, Alanna C.
dc.contributor.authorHall, Ian P.
dc.contributor.authorTobin, Martin D.
dc.contributor.authorLondon, Stephanie J.
dc.date.accessioned2018-10-29T05:41:52Z
dc.date.available2018-10-29T05:41:52Z
dc.date.issued2018fi
dc.identifier.citationJackson, V. E., Latourelle, J. C., Wain, L. V., Smith, A. V., Grove, M. L., Bartz, T. M., . . . London, S. J. (2018). Meta-analysis of exome array data identifies six novel genetic loci for lung function. <em>Wellcome Open Research</em>, 3, 4. <a href="https://doi.org/10.12688/wellcomeopenres.12583.3">doi:10.12688/wellcomeopenres.12583.3</a>fi
dc.identifier.otherTUTKAID_79066
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/59972
dc.description.abstractBackground: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and the ratio of FEV1 to FVC (FEV1/FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 individuals of European ancestry from 23 studies, and 7,721 individuals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent individuals. Results: We identified significant (P<2·8x10-7) associations with six SNPs: a nonsynonymous variant in RPAP1, which is predicted to be damaging, three intronic SNPs (SEC24C, CASC17 and UQCC1) and two intergenic SNPs near to LY86 and FGF10. Expression quantitative trait loci analyses found evidence for regulation of gene expression at three signals and implicated several genes, including TYRO3 and PLAU. Conclusions: Further interrogation of these loci could provide greater understanding of the determinants of lung function and pulmonary disease.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWellcome Trust
dc.relation.ispartofseriesWellcome Open Research
dc.rightsCC BY 4.0
dc.subject.otherkeuhkotfi
dc.subject.otherhengityselimetfi
dc.subject.otherlung functionfi
dc.subject.otherrespiratoryfi
dc.subject.otherexome arrayfi
dc.titleMeta-analysis of exome array data identifies six novel genetic loci for lung functionfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201810044349
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-10-04T12:15:06Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn2398-502X
dc.relation.numberinseries0
dc.relation.volume3
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 Jackson VE et al.
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.12688/wellcomeopenres.12583.3


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