Show simple item record

dc.contributor.authorPalin, Kimmo
dc.contributor.authorPitkänen, Esa
dc.contributor.authorTurunen, Mikko
dc.contributor.authorSahu, Biswajyoti
dc.contributor.authorPihlajamaa, Päivi
dc.contributor.authorKivioja, Teemu
dc.contributor.authorKaasinen, Eevi
dc.contributor.authorVälimäki, Niko
dc.contributor.authorHänninen, Ulrika A.
dc.contributor.authorCajuso, Tatiana
dc.contributor.authorAavikko, Mervi
dc.contributor.authorTuupanen, Sari
dc.contributor.authorKilpivaara, Outi
dc.contributor.authorvan den Berg, Linda
dc.contributor.authorKondelin, Johanna
dc.contributor.authorTanskanen, Tomas
dc.contributor.authorKatainen, Riku
dc.contributor.authorGrau, Marta
dc.contributor.authorRauanheimo, Heli
dc.contributor.authorPlaketti, Roosa-Maria
dc.contributor.authorTaira, Aurora
dc.contributor.authorSulo, Päivi
dc.contributor.authorHartonen, Tuomo
dc.contributor.authorDave, Kashyap
dc.contributor.authorSchmierer, Bernhard
dc.contributor.authorBotla, Sandeep
dc.contributor.authorSokolova, Maria
dc.contributor.authorVähärautio, Anna
dc.contributor.authorGladysz, Kornelia
dc.contributor.authorOngen, Halit
dc.contributor.authorDermitzakis, Emmanouil
dc.contributor.authorBramsen, Jesper Bertram
dc.contributor.authorØrntoft, Torben Falck
dc.contributor.authorAndersen, Claus Lindbjerg
dc.contributor.authorRistimäki, Ari
dc.contributor.authorLepistö, Anna
dc.contributor.authorRenkonen-Sinisalo, Laura
dc.contributor.authorMecklin, Jukka-Pekka
dc.contributor.authorTaipale, Jussi
dc.contributor.authorAaltonen, Lauri A.
dc.date.accessioned2018-09-26T05:31:00Z
dc.date.available2018-09-26T05:31:00Z
dc.date.issued2018
dc.identifier.citationPalin, K., Pitkänen, E., Turunen, M., Sahu, B., Pihlajamaa, P., Kivioja, T., Kaasinen, E., Välimäki, N., Hänninen, U. A., Cajuso, T., Aavikko, M., Tuupanen, S., Kilpivaara, O., van den Berg, L., Kondelin, J., Tanskanen, T., Katainen, R., Grau, M., Rauanheimo, H., . . . Aaltonen, L. A. (2018). Contribution of allelic imbalance to colorectal cancer. <i>Nature Communications</i>, <i>9</i>, Article 3664. <a href="https://doi.org/10.1038/s41467-018-06132-1" target="_blank">https://doi.org/10.1038/s41467-018-06132-1</a>
dc.identifier.otherCONVID_28261137
dc.identifier.otherTUTKAID_78824
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/59661
dc.description.abstractPoint mutations in cancer have been extensively studied but chromosomal gains and losses have been more challenging to interpret due to their unspecific nature. Here we examine high-resolution allelic imbalance (AI) landscape in 1699 colorectal cancers, 256 of which have been whole-genome sequenced (WGSed). The imbalances pinpoint 38 genes as plausible AI targets based on previous knowledge. Unbiased CRISPR-Cas9 knockout and activation screens identified in total 79 genes within AI peaks regulating cell growth. Genetic and functional data implicate loss of TP53 as a sufficient driver of AI. The WGS highlights an influence of copy number aberrations on the rate of detected somatic point mutations. Importantly, the data reveal several associations between AI target genes, suggesting a role for a network of lineage-determining transcription factors in colorectal tumorigenesis. Overall, the results unravel the contribution of AI in colorectal cancer and provide a plausible explanation why so few genes are commonly affected by point mutations in cancers.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesNature Communications
dc.rightsCC BY 4.0
dc.subject.othercolorectal cancer
dc.titleContribution of allelic imbalance to colorectal cancer
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201809174145
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-09-17T15:15:08Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn2041-1723
dc.relation.numberinseries0
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© The Authors, 2018
dc.rights.accesslevelopenAccessfi
dc.subject.ysopaksusuolisyöpä
dc.subject.ysosyöpägeenit
dc.subject.ysomutaatiot
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p5937
jyx.subject.urihttp://www.yso.fi/onto/yso/p23580
jyx.subject.urihttp://www.yso.fi/onto/yso/p15346
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41467-018-06132-1


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY 4.0
Except where otherwise noted, this item's license is described as CC BY 4.0