Show simple item record

dc.contributor.authorShu, Tao
dc.contributor.authorZhao, Long
dc.contributor.authorLi, Sun
dc.contributor.authorChen, Xiang-Yu
dc.contributor.authorvon Essen, Carolina
dc.contributor.authorRissanen, Kari
dc.contributor.authorEnders, Dieter
dc.date.accessioned2018-08-14T12:53:44Z
dc.date.issued2018fi
dc.identifier.citationShu, T., Zhao, L., Li, S., Chen, X.-Y., von Essen, C., Rissanen, K., & Enders, D. (2018). Asymmetric Synthesis of Spirocyclic β‐Lactams via Copper‐Catalyzed Kinugasa/Michael Domino Reactions. <em>Angewandte Chemie</em>, 130 (34), 11151-11154. <a href="https://doi.org/10.1002/ange.201806931">doi:10.1002/ange.201806931</a>fi
dc.identifier.otherTUTKAID_78221
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/59213
dc.description.abstractThe first copper‐catalyzed highly chemo‐, regio‐, diastereo‐, and enantioselective Kinugasa/Michael domino reaction for the desymmetrization of prochiral cyclohexadienones is described. In the presence of a chiral copper catalyst, alkyne‐tethered cyclohexadienones couple with nitrones to generate the chiral spirocyclic lactams with excellent stereoselectivity (up to 97 % ee, >20:1 dr). The new method provides direct access to versatile highly functionalized spirocyclic β‐lactams possessing four contiguous stereocenters, including one quaternary and one tetra‐substituted stereocenter.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofseriesAngewandte Chemie
dc.rightsIn Copyright
dc.subject.otherasymmetric synthesisfi
dc.titleAsymmetric Synthesis of Spirocyclic β‐Lactams via Copper‐Catalyzed Kinugasa/Michael Domino Reactionsfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201808143826
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemia
dc.date.embargo2019-07-04
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-08-14T09:15:06Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange11151-11154
dc.relation.issn1433-7851
dc.relation.numberinseries34
dc.relation.volume130
dc.type.versionFinal Draft
dc.rights.copyright© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1002/ange.201806931


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

In Copyright
Except where otherwise noted, this item's license is described as In Copyright