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dc.contributor.authorShu, Tao
dc.contributor.authorZhao, Long
dc.contributor.authorLi, Sun
dc.contributor.authorChen, Xiang-Yu
dc.contributor.authorvon Essen, Carolina
dc.contributor.authorRissanen, Kari
dc.contributor.authorEnders, Dieter
dc.date.accessioned2018-08-14T12:53:44Z
dc.date.issued2018fi
dc.identifier.citationShu, T., Zhao, L., Li, S., Chen, X.-Y., von Essen, C., Rissanen, K., & Enders, D. (2018). Asymmetric Synthesis of Spirocyclic β‐Lactams via Copper‐Catalyzed Kinugasa/Michael Domino Reactions. <em>Angewandte Chemie</em>, 130 (34), 11151-11154. <a href="https://doi.org/10.1002/ange.201806931">doi:10.1002/ange.201806931</a>fi
dc.identifier.otherTUTKAID_78221
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/59213
dc.description.abstractThe first copper‐catalyzed highly chemo‐, regio‐, diastereo‐, and enantioselective Kinugasa/Michael domino reaction for the desymmetrization of prochiral cyclohexadienones is described. In the presence of a chiral copper catalyst, alkyne‐tethered cyclohexadienones couple with nitrones to generate the chiral spirocyclic lactams with excellent stereoselectivity (up to 97 % ee, >20:1 dr). The new method provides direct access to versatile highly functionalized spirocyclic β‐lactams possessing four contiguous stereocenters, including one quaternary and one tetra‐substituted stereocenter.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofseriesAngewandte Chemie
dc.rightsIn Copyright
dc.subject.otherasymmetric synthesisfi
dc.titleAsymmetric Synthesis of Spirocyclic β‐Lactams via Copper‐Catalyzed Kinugasa/Michael Domino Reactionsfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201808143826
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemia
dc.date.embargo2019-07-04
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.identifier.doi10.1002/ange.201806931
dc.date.updated2018-08-14T09:15:06Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange11151-11154
dc.relation.issn1433-7851
dc.relation.numberinseries34
dc.relation.volume130
dc.type.versionFinal Draft
dc.rights.copyright© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en


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