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dc.contributor.authorGouveia, Marisol
dc.contributor.authorFigueira, João
dc.contributor.authorJardim, Manuel G.
dc.contributor.authorCastro, Rita
dc.contributor.authorTomás, Helena
dc.contributor.authorRissanen, Kari
dc.contributor.authorRodrigues, João
dc.date.accessioned2018-06-25T07:34:45Z
dc.date.available2018-06-25T07:34:45Z
dc.date.issued2018
dc.identifier.citationGouveia, M., Figueira, J., Jardim, M. G., Castro, R., Tomás, H., Rissanen, K., & Rodrigues, J. (2018). Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells. <i>Molecules</i>, <i>23</i>(6), Article 1471. <a href="https://doi.org/10.3390/molecules23061471" target="_blank">https://doi.org/10.3390/molecules23061471</a>
dc.identifier.otherCONVID_28121780
dc.identifier.otherTUTKAID_78018
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/58716
dc.description.abstractHere and for the first time, we show that the organometallic compound [Ru(η5-C5H5)(PPh3)2Cl] (RuCp) has potential to be used as a metallodrug in anticancer therapy, and further present a new approach for the cellular delivery of the [Ru(η5-C5H5)(PPh3)2]+ fragment via coordination on the periphery of low-generation poly(alkylidenimine) dendrimers through nitrile terminal groups. Importantly, both the RuCp and the dendrimers functionalized with [Ru(η5-C5H5)(PPh3)2]+ fragments present remarkable toxicity towards a wide set of cancer cells (Caco-2, MCF-7, CAL-72, and A2780 cells), including cisplatin-resistant human ovarian carcinoma cell lines (A2780cisR cells). Also, RuCp and the prepared metallodendrimers are active against human mesenchymal stem cells (hMSCs), which are often found in the tumor microenvironment where they seem to play a role in tumor progression and drug resistance.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesMolecules
dc.rightsCC BY 4.0
dc.subject.otherdendrimers
dc.subject.othernanocarriers
dc.subject.othermetallodrugs
dc.subject.otherruthenium
dc.subject.othercisplatin
dc.subject.othercancer treatment
dc.subject.otherhMSCs
dc.titlePoly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201806193261
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemiafi
dc.contributor.oppiaineOrganic Chemistryen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-06-19T09:15:12Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn1420-3049
dc.relation.numberinseries6
dc.relation.volume23
dc.type.versionacceptedVersion
dc.rights.copyright© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
dc.rights.accesslevelopenAccessfi
dc.subject.ysomolekyylit
dc.subject.ysometallit
dc.subject.ysolääkkeet
dc.subject.ysoplatina
dc.subject.ysokantasolut
dc.subject.ysosyöpähoidot
dc.subject.ysomyrkyllisyys
dc.subject.ysonanolääketiede
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p2984
jyx.subject.urihttp://www.yso.fi/onto/yso/p3097
jyx.subject.urihttp://www.yso.fi/onto/yso/p1077
jyx.subject.urihttp://www.yso.fi/onto/yso/p12535
jyx.subject.urihttp://www.yso.fi/onto/yso/p13517
jyx.subject.urihttp://www.yso.fi/onto/yso/p27422
jyx.subject.urihttp://www.yso.fi/onto/yso/p12637
jyx.subject.urihttp://www.yso.fi/onto/yso/p28422
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/molecules23061471


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