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dc.contributor.authorKumar, Mukesh
dc.contributor.authorChauhan, Pankaj
dc.contributor.authorBailey, Stephen J.
dc.contributor.authorJafari, Ehsan
dc.contributor.authorvon Essen, Carolina
dc.contributor.authorRissanen, Kari
dc.contributor.authorEnders, Dieter
dc.date.accessioned2018-05-23T07:11:02Z
dc.date.available2019-02-06T22:35:24Z
dc.date.issued2018fi
dc.identifier.citationKumar, M., Chauhan, P., Bailey, S. J., Jafari, E., von Essen, C., Rissanen, K., & Enders, D. (2018). Organocatalytic Oxa-Michael/Michael/Michael/Aldol Condensation Quadruple Domino Sequence : Asymmetric Synthesis of Tricyclic Chromanes. <em>Organic Letters</em>, 20 (4), 1232-1235. <a href="https://doi.org/10.1021/acs.orglett.8b00175">doi:10.1021/acs.orglett.8b00175</a>fi
dc.identifier.otherTUTKAID_76774
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/58077
dc.description.abstractAn efficient and highly stereoselective one-pot, four-component synthesis of functionalized tricyclic chromanes has been achieved through an organocatalyzed quadruple domino reaction. The reaction sequence involves an oxa-Michael/Michael/Michael/aldol condensation between alcohols, 2 equiv of acrolein, and nitrochromenes to generate the pharmaceutically important tricyclic chromanes bearing three contiguous stereogenic centers including a chiral tetrasubstituted carbon center in good domino yields (30–70%) and excellent diastereo- and enantioselectivities (>20:1 dr and >99% ee).fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofseriesOrganic Letters
dc.rightsIn Copyright
dc.subject.otherasymmetriafi
dc.subject.othersynteesifi
dc.subject.otheralkoholit (yhdisteet)fi
dc.subject.otherluonnontuotteetfi
dc.subject.otherdomino reactionsfi
dc.subject.otherasymmetric synthesisfi
dc.subject.otherasymmetryfi
dc.subject.othersynthesisfi
dc.subject.othertricyclic chromanesfi
dc.subject.otheralcohols (organic compounds)fi
dc.subject.othernatural productsfi
dc.titleOrganocatalytic Oxa-Michael/Michael/Michael/Aldol Condensation Quadruple Domino Sequence : Asymmetric Synthesis of Tricyclic Chromanesfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201805222711
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.identifier.doi10.1021/acs.orglett.8b00175
dc.date.updated2018-05-22T09:15:10Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1232-1235
dc.relation.issn1523-7060
dc.relation.numberinseries4
dc.relation.volume20
dc.type.versionFinal Draft
dc.rights.copyright© 2018 American Chemical Society
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en


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