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dc.contributor.authorSoikkeli, Maiju
dc.contributor.authorHorkka, Kaisa
dc.contributor.authorMoilanen, Jani
dc.contributor.authorTimonen, Marjut
dc.contributor.authorKavakka, Jari
dc.contributor.authorHeikkinen, Sami
dc.date.accessioned2018-05-03T08:22:40Z
dc.date.available2018-05-03T08:22:40Z
dc.date.issued2018
dc.identifier.citationSoikkeli, M., Horkka, K., Moilanen, J., Timonen, M., Kavakka, J., & Heikkinen, S. (2018). Synthesis, Stability and Relaxivity of TEEPO-Met : An Organic Radical as a Potential Tumour Targeting Contrast Agent for Magnetic Resonance Imaging. <i>Molecules</i>, <i>23</i>(5), Article 1034. <a href="https://doi.org/10.3390/molecules23051034" target="_blank">https://doi.org/10.3390/molecules23051034</a>
dc.identifier.otherCONVID_28031268
dc.identifier.otherTUTKAID_77526
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/57828
dc.description.abstractCancer is a widespread and life-threatening disease and its early-stage diagnosis is vital. One of the most effective, non-invasive tools in medical diagnostics is magnetic resonance imaging (MRI) with the aid of contrast agents. Contrast agents that are currently in clinical use contain metals, causing some restrictions in their use. Also, these contrast agents are mainly non-specific without any tissue targeting capabilities. Subsequently, the interest has notably increased in the research of organic, metal-free contrast agents. This study presents a new, stable organic radical, TEEPO-Met, where a radical moiety 2,2,6,6-tetraethylpiperidinoxide (TEEPO) is attached to an amino acid, methionine (Met), as a potentially tumour-targeting moiety. We describe the synthesis, stability assessment with electron paramagnetic resonance (EPR) spectroscopy and relaxation enhancement abilities by an in vitro nuclear magnetic resonance (NMR) and phantom MRI studies of TEEPO-Met. The new compound proved to be stable notably longer than the average imaging time in conditions mimicking a biological matrix. Also, it significantly reduced the relaxation times of water, making it a promising candidate as a novel tumour targeting contrast agent for MRI.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.ispartofseriesMolecules
dc.subject.othermagneettitutkimus
dc.subject.othernitroxides
dc.subject.otherradicals
dc.subject.othermethionine
dc.subject.othercontrast agents
dc.titleSynthesis, Stability and Relaxivity of TEEPO-Met : An Organic Radical as a Potential Tumour Targeting Contrast Agent for Magnetic Resonance Imaging
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201804302402
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineEpäorgaaninen ja analyyttinen kemiafi
dc.contributor.oppiaineNanoscience Centerfi
dc.contributor.oppiaineInorganic and Analytical Chemistryen
dc.contributor.oppiaineNanoscience Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-04-30T12:15:02Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn1420-3049
dc.relation.numberinseries5
dc.relation.volume23
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the terms of the Creative Commons License.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoorgaaniset yhdisteet
dc.subject.ysovapaat radikaalit
dc.subject.ysovarjoainetutkimus
dc.subject.ysotyppiyhdisteet
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p3841
jyx.subject.urihttp://www.yso.fi/onto/yso/p2983
jyx.subject.urihttp://www.yso.fi/onto/yso/p14680
jyx.subject.urihttp://www.yso.fi/onto/yso/p640
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/molecules23051034
dc.type.okmA1


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© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the terms of the Creative Commons License.
Except where otherwise noted, this item's license is described as © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the terms of the Creative Commons License.