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dc.contributor.authorRauramaa, Tuomas
dc.contributor.authorSaxlin, Anna
dc.contributor.authorLohvansuu, Kaisa
dc.contributor.authorAlafuzoff, Irina
dc.contributor.authorPitkänen, Asla
dc.contributor.authorSoininen, Hilkka
dc.date.accessioned2018-04-09T09:22:00Z
dc.date.available2019-06-02T21:35:38Z
dc.date.issued2018
dc.identifier.citationRauramaa, T., Saxlin, A., Lohvansuu, K., Alafuzoff, I., Pitkänen, A., & Soininen, H. (2018). Epilepsy in neuropathologically verified Alzheimer's disease. <i>Seizure : European Journal of Epilepsy</i>, <i>58</i>, 9-12. <a href="https://doi.org/10.1016/j.seizure.2018.03.014" target="_blank">https://doi.org/10.1016/j.seizure.2018.03.014</a>
dc.identifier.otherCONVID_27955142
dc.identifier.otherTUTKAID_77096
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/57510
dc.description.abstractPurpose Subjects with Alzheimer’s disease (AD) have been shown to be at a higher risk for epilepsy. The vast majority of the previous studies have not included a full neuropathological examination. Methods The objective of this study was to assess the prevalence of epilepsy and clinicopathological characteristics in a well-defined study group of 64 subjects with AD. We evaluated the clinicopathological findings in 64 subjects (mean age at death 85 ± 8.6 years) from a longitudi-nal study cohort of patients with dementia. Results Eleven out of the 64 subjects (17%) had a history of epilepsy, which is comparable to previous studies. The subjects with AD and epilepsy were significantly younger at the time of AD diagnosis and at the time of hospitalisation. In addition, their duration of AD was longer. Concomitant neuropathology in addition to AD was common in both groups and the ApoE genotypes did not differ significantly between the groups. Conclusion The strength of this study is a thorough neuropathological examination of all study subjects. Our findings support the previous literature regarding the prevalence of epilepsy in subjects with AD. We have shown that the subjects with AD and epilepsy differ significantly from the subjects without epilepsy.
dc.language.isoeng
dc.publisherElsevier Ltd.
dc.relation.ispartofseriesSeizure : European Journal of Epilepsy
dc.subject.otheralzheimer
dc.subject.otherneurodegeneration
dc.titleEpilepsy in neuropathologically verified Alzheimer's disease
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201803281870
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-03-28T12:15:14Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange9-12
dc.relation.issn1059-1311
dc.relation.numberinseries0
dc.relation.volume58
dc.type.versionacceptedVersion
dc.rights.copyright© 2018 British Epilepsy Association This is a final draft version of an article whose final and definitive form has been published by Elsevier Ltd. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoAlzheimerin tauti
dc.subject.ysodementia
dc.subject.ysoruumiinavaus
dc.subject.ysoneurodegeneratiiviset sairaudet
dc.subject.ysoepilepsia
jyx.subject.urihttp://www.yso.fi/onto/yso/p8412
jyx.subject.urihttp://www.yso.fi/onto/yso/p1711
jyx.subject.urihttp://www.yso.fi/onto/yso/p3963
jyx.subject.urihttp://www.yso.fi/onto/yso/p28721
jyx.subject.urihttp://www.yso.fi/onto/yso/p9413
dc.relation.doi10.1016/j.seizure.2018.03.014
dc.type.okmA1


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