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dc.contributor.authorKunutsor, Setor K.
dc.contributor.authorLaukkanen, Jari
dc.contributor.authorBurgess, Stephen
dc.date.accessioned2018-03-12T11:30:02Z
dc.date.available2018-03-12T11:30:02Z
dc.date.issued2018
dc.identifier.citationKunutsor, S. K., Laukkanen, J., & Burgess, S. (2018). Genetically elevated gamma-glutamyltransferase and Alzheimer's disease. <i>Experimental Gerontology</i>, <i>106</i>, 61-66. <a href="https://doi.org/10.1016/j.exger.2018.03.001" target="_blank">https://doi.org/10.1016/j.exger.2018.03.001</a>
dc.identifier.otherCONVID_27927992
dc.identifier.otherTUTKAID_76951
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/57304
dc.description.abstractObservational epidemiological evidence supports a linear and independent association between serum gamma-glutamyltransferase (GGT) concentrations and the risk of Alzheimer's disease (AD). However, the causality of this association has not been previously investigated. We sought to assess the causal nature of this association using a Mendelian randomization (MR) approach. Using inverse-variance weighted MR analysis, we assessed the association between GGT and AD using summary statistics for single nucleotide polymorphism (SNP)-AD associations obtained from the International Genomics of Alzheimer's Project of 17,008 individuals with AD and 37,154 controls. We used 26 SNPs significantly associated with GGT in a previous genome-wide association study on liver enzymes as instruments. Sensitivity analyses to account for potential genetic pleiotropy included MR-Egger and weighted median MR. The odds ratio of AD was 1.09 (95% confidence interval, 0.98 to 1.22; p  =  0.10) per one standard deviation genetically elevated GGT based on all 26 SNPs. The results were similar in both MR-Egger and weighted median MR methods. Overall, our findings cannot confirm a strong causal effect of GGT on AD risk. Further MR investigations using individual-level data are warranted to confirm or rule out causality.
dc.language.isoeng
dc.publisherElsevier Inc.
dc.relation.ispartofseriesExperimental Gerontology
dc.subject.otherGamma-glutamyltransferase
dc.subject.otherMendelian randomization
dc.titleGenetically elevated gamma-glutamyltransferase and Alzheimer's disease
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201803121706
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-03-12T07:15:04Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange61-66
dc.relation.issn0531-5565
dc.relation.numberinseries0
dc.relation.volume106
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 The Authors. Published by Elsevier Inc. This is an open access article distributed under the terms of the Creative Commons License.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoAlzheimerin tauti
dc.subject.ysogeneettiset tekijät
dc.subject.ysoentsyymit
dc.subject.ysotransferaasit
jyx.subject.urihttp://www.yso.fi/onto/yso/p8412
jyx.subject.urihttp://www.yso.fi/onto/yso/p21661
jyx.subject.urihttp://www.yso.fi/onto/yso/p4769
jyx.subject.urihttp://www.yso.fi/onto/yso/p21692
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1016/j.exger.2018.03.001


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© 2018 The Authors. Published by Elsevier Inc. This is an open access article distributed under the terms of the Creative Commons License.
Except where otherwise noted, this item's license is described as © 2018 The Authors. Published by Elsevier Inc. This is an open access article distributed under the terms of the Creative Commons License.