Show simple item record

dc.contributor.authorKurkela, Jari
dc.contributor.authorLipponen, Arto
dc.contributor.authorKyläheiko, Iiris
dc.contributor.authorAstikainen, Piia
dc.date.accessioned2018-02-23T11:17:48Z
dc.date.available2018-02-23T11:17:48Z
dc.date.issued2018
dc.identifier.citationKurkela, J., Lipponen, A., Kyläheiko, I., & Astikainen, P. (2018). Electrophysiological evidence of memory-based detection of auditory regularity violations in anesthetized mice. <i>Scientific Reports</i>, <i>8</i>, Article 3027. <a href="https://doi.org/10.1038/s41598-018-21411-z" target="_blank">https://doi.org/10.1038/s41598-018-21411-z</a>
dc.identifier.otherCONVID_27910605
dc.identifier.otherTUTKAID_76859
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/57165
dc.description.abstractIn humans, automatic change detection is reflected by an electrical brain response called mismatch negativity (MMN). Mismatch response is also elicited in mice, but it is unclear to what extent it is functionally similar to human MMN. We investigated this possible similarity by recording local field potentials from the auditory cortex of anesthetized mice. First, we tested whether the response to stimulus changes reflected the detection of regularity violations or adaptation to standard stimuli. Responses obtained from an oddball condition, where occasional changes in frequency were presented amongst of a standard sound, were compared to responses obtained from a control condition, where no regularities existed. To test whether the differential response to the deviant sounds in the oddball condition is dependent on sensory memory, responses from the oddball condition using 375 ms and 600 ms inter-stimulus intervals (ISI) were compared. We found a differential response to deviant sounds which was larger with the shorter than the longer ISI. Furthermore, the oddball deviant sound elicited larger response than the same sound in the control condition. These results demonstrate that the mismatch response in mice reflects detection of regularity violations and sensory memory function, as the human MMN.
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.subject.otherelektrofysiologia
dc.subject.otherkuulohavainnot
dc.subject.otherkuulomuisti
dc.subject.otherpoikkeavuusnegatiivisuus
dc.subject.otherelectrophysiology
dc.subject.otherauditory perceptions
dc.subject.otherauditory memory
dc.subject.othermismatch negativity
dc.titleElectrophysiological evidence of memory-based detection of auditory regularity violations in anesthetized mice
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201802221569
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiainePsychologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-02-22T13:15:19Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.numberinseries0
dc.relation.volume8
dc.type.versionpublishedVersion
dc.rights.copyright© the Authors, 2018. This is an open access article distributed under the terms of the Creative Commons License.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoelektrofysiologia
dc.subject.ysokuulohavainnot
dc.subject.ysokuulomuisti
dc.subject.ysopoikkeavuusnegatiivisuus
jyx.subject.urihttp://www.yso.fi/onto/yso/p7871
jyx.subject.urihttp://www.yso.fi/onto/yso/p23127
jyx.subject.urihttp://www.yso.fi/onto/yso/p28081
jyx.subject.urihttp://www.yso.fi/onto/yso/p26013
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41598-018-21411-z


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

© the Authors, 2018. This is an open access article distributed under the terms of the Creative Commons License.
Except where otherwise noted, this item's license is described as © the Authors, 2018. This is an open access article distributed under the terms of the Creative Commons License.