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dc.contributor.authorMunukka, Matti
dc.contributor.authorWaller, Benjamin
dc.contributor.authorHäkkinen, Arja
dc.contributor.authorNieminen, Miika T.
dc.contributor.authorLammentausta, Eveliina
dc.contributor.authorKujala, Urho
dc.contributor.authorPaloneva, Juha
dc.contributor.authorKautiainen, Hannu
dc.contributor.authorKiviranta, Ilkka
dc.contributor.authorHeinonen, Ari
dc.date.accessioned2018-01-15T12:21:38Z
dc.date.available2018-07-01T21:35:46Z
dc.date.issued2017
dc.identifier.citationMunukka, M., Waller, B., Häkkinen, A., Nieminen, M. T., Lammentausta, E., Kujala, U., Paloneva, J., Kautiainen, H., Kiviranta, I., & Heinonen, A. (2017). Physical Activity Is Related with Cartilage Quality in Women with Knee Osteoarthritis. <i>Medicine and Science in Sports and Exercise</i>, <i>49</i>(7), 1323-1330. <a href="https://doi.org/10.1249/MSS.0000000000001238" target="_blank">https://doi.org/10.1249/MSS.0000000000001238</a>
dc.identifier.otherCONVID_26885425
dc.identifier.otherTUTKAID_73137
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/56738
dc.description.abstractPurpose To study the relationship between 12-month leisure-time physical activity (LTPA) level and changes in estimated biochemical composition of tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis (OA). Methods Originally, 87 volunteer postmenopausal women, age 60 to 68 yr, with mild knee OA (Kellgren Lawrence I/II and knee pain) participated in a randomized controlled, 4-month aquatic training trial (RCT), after which 76 completed the 12-month postintervention follow-up period. Self-reported LTPA was collected along the 12-month period using a diary from which MET task hours per month were calculated. Participants were divided into MET task hour tertiles: 1, lowest (n = 25); 2 = middle (n = 25) and 3 = highest (n = 26). The biochemical composition of the cartilage was estimated using transverse relaxation time (T2) mapping sensitive to the properties of the collagen network and delayed gadolinium-enhanced magnetic resonance imaging of the cartilage (dGEMRIC index) sensitive to the cartilage glycosaminoglycan content. Secondary outcomes were cardiorespiratory fitness, isometric knee extension and flexion force, and the knee injury and OA outcome questionnaire. Results During the 12-month follow-up period, there was a significant linear relationship between higher LTPA level and increased dGEMRIC index changes in the posterior region of interest (ROI) of the lateral (P = 0.003 for linearity) and medial (P = 0.006) femoral cartilage. Furthermore, these changes were seen in the posterior lateral femoral cartilage superficial (P = 0.004) and deep (P = 0.007) ROI and in the posterior medial superficial ROI (P < 0.001). There was no linear relationship between LTPA level and other measured variables. Conclusions These results suggest that higher LTPA level is related to regional increases in estimated glycosaminoglycan content of tibiofemoral cartilage in postmenopausal women with mild knee OA as measured with dGEMRIC index during a 12-month period.
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofseriesMedicine and Science in Sports and Exercise
dc.subject.othercartilage composition
dc.subject.otherleisure-time physical activity
dc.subject.otherMET
dc.subject.otherquantitative magnetic resonance imaging
dc.subject.otherpostmenopausal women
dc.titlePhysical Activity Is Related with Cartilage Quality in Women with Knee Osteoarthritis
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201801151187
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineFysioterapiafi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiainePhysiotherapyen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-01-15T10:15:35Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1323-1330
dc.relation.issn0195-9131
dc.relation.numberinseries7
dc.relation.volume49
dc.type.versionacceptedVersion
dc.rights.copyright© 2017 by the American College of Sports Medicine. This is a final draft version of an article whose final and definitive form has been published by LWW. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.subject.ysonivelrikko
dc.subject.ysorusto
dc.subject.ysopolvet
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysoseurantatutkimus
jyx.subject.urihttp://www.yso.fi/onto/yso/p12334
jyx.subject.urihttp://www.yso.fi/onto/yso/p21729
jyx.subject.urihttp://www.yso.fi/onto/yso/p14204
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p13719
dc.relation.doi10.1249/MSS.0000000000001238


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