Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence
Remete, A. M., Nonn, M., Fustero, S., Haukka, M., Fülöp, F., & Kiss, L. (2017). Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence. Beilstein Journal of Organic Chemistry, 13, 2364-2371. doi:10.3762/bjoc.13.233
Published inBeilstein Journal of Organic Chemistry
DisciplineEpäorgaaninen ja analyyttinen kemia
© 2017 Remete et al.; licensee Beilstein-Institut. This is an open access article distributed under the terms of a Creative Commons License.
A study exploring the chemical behavior of some dihydroxylated β-amino ester stereo- and regioisomers, derived from unsaturated cyclic β-amino acids is described. The nucleophilic fluorinations involving hydroxy–fluorine exchange of some highly functionalized alicyclic diol derivatives have been carried out in view of selective fluorination, investigating substrate dependence, neighboring group assistance and chemodifferentiation.