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dc.contributor.authorHirvasniemi, Jukka
dc.contributor.authorThevenot, Jérôme
dc.contributor.authorMultanen, Juhani
dc.contributor.authorHaapea, Marianne
dc.contributor.authorHeinonen, Ari
dc.contributor.authorNieminen, Miika T.
dc.contributor.authorSaarakkala, Simo
dc.date.accessioned2017-11-16T10:08:07Z
dc.date.available2017-11-16T10:08:07Z
dc.date.issued2017
dc.identifier.citationHirvasniemi, J., Thevenot, J., Multanen, J., Haapea, M., Heinonen, A., Nieminen, M. T., & Saarakkala, S. (2017). Association between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis. <em>Osteoarthritis and Cartilage</em>, 25 (12), 2039-2046. <a href="https://doi.org/10.1016/j.joca.2017.09.008">doi:10.1016/j.joca.2017.09.008</a>
dc.identifier.otherTUTKAID_75190
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/55894
dc.description.abstractObjective: Our aim was to investigate the relation between radiograph-based subchondral bone structure and cartilage composition assessed with delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 relaxation time. Design: Ninety-three postmenopausal women (KellgreneLawrence grade 0: n ¼ 13, 1: n ¼ 26, 2: n ¼ 54) were included. Radiograph-based bone structure was assessed using entropy of the Laplacian-based image (ELap) and local binary patterns (ELBP), homogeneity indices of the local angles (HIAngles,mean, HIAngles,Perp, HIAngles,Paral), and horizontal (FDHor) and vertical fractal dimensions (FDVer). Mean dGEMRIC index and T2 relaxation time of tibial cartilage were calculated to estimate cartilage composition. Results: HIAngles,mean (rs ¼ 0.22) and HIAngles,Paral (rs ¼ 0.24) in medial subchondral bone were related (P < 0.05) to dGEMRIC index of the medial tibial cartilage. ELap (rs ¼ 0.23), FDHor,0.34 mm (r ¼ 0.21) and FDVer,0.68 mm (r ¼ 0.24) in medial subchondral bone were related (P < 0.05) to T2 relaxation time values of the medial tibial cartilage. FDHor at different scales in lateral subchondral bone were related (P < 0.01) to dGEMRIC index (r ¼ 0.29e0.41) and T2 values of lateral tibial cartilage (r ¼ 0.28 to 0.36). FDVer at larger scales were related (P < 0.05) to dGEMRIC index (r ¼ 0.24e0.25) and T2 values of lateral tibial cartilage (r ¼ 0.21). HIAngles,Paral (r ¼ 0.25) and FDVer,0.68 mm (rs ¼ 0.22) in the lateral tibial trabecular bone were related (P < 0.05) to dGEMRIC index of the lateral tibial cartilage. Conclusion: Our results support the presumption that several tissues are affected in the early osteoarthritis (OA). Furthermore, they indicate that the detailed analysis of radiographs may serve as a complementary imaging tool for OA studies.
dc.language.isoeng
dc.publisherElsevier Ltd; OsteoArthritis Research Society International
dc.relation.ispartofseriesOsteoarthritis and Cartilage
dc.subject.othernivelrikko
dc.subject.otherpolvet
dc.subject.otherluu
dc.subject.otherrusto
dc.subject.otherröntgentutkimus
dc.subject.othermagneettitutkimus
dc.subject.otherradiographers
dc.subject.otherbone
dc.subject.otherradiography
dc.subject.otherMRI
dc.subject.otherosteoarthritis
dc.subject.otherbone structure
dc.subject.othercartilage composition
dc.subject.otherknees
dc.titleAssociation between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201711134225
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineFysioterapia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-11-13T07:15:05Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2039-2046
dc.relation.issn1063-4584
dc.relation.volume25
dc.type.versionpublishedVersion
dc.rights.copyright© 2017 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY-NC-ND license.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.joca.2017.09.008


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© 2017 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society
International. This is an open access article under the CC BY-NC-ND license.
Except where otherwise noted, this item's license is described as © 2017 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY-NC-ND license.