Enantioselective synthesis of pyrazolone α-aminonitrile derivatives via an organocatalytic Strecker reaction

Mahajan, Suruchi; Chauhan, Pankaj; Kaya, Uğur; Deckers, Kristina; Rissanen, Kari; Enders, Dieter

doi:10.1039/C7CC02874A

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Mahajan, S., Chauhan, P., Kaya, U., Deckers, K., Rissanen, K., & Enders, D. (2017). Enantioselective synthesis of pyrazolone α-aminonitrile derivatives via an organocatalytic Strecker reaction. Chemical Communications, 53(49), 6633-6636. https://doi.org/10.1039/C7CC02874A

Julkaistu sarjassa

Chemical Communications

Tekijät

Mahajan, Suruchi |

Chauhan, Pankaj |

Kaya, Uğur |

Deckers, Kristina |

Rissanen, Kari |

Enders, Dieter

Päivämäärä

2017

Oppiaine

Orgaaninen kemia Nanoscience Center Organic Chemistry Nanoscience Center

Tekijänoikeudet

© The Royal Society of Chemistry 2017. This is a final draft version of an article whose final and definitive form has been published by RSC. Published in this repository with the kind permission of the publisher.

A new organocatalytic enantioselective Strecker reaction of pyrazolone-derived ketimine electrophiles has been developed. Using pseudo-enantiomeric squaramide catalysts the nucleophilic 1,2-addition of trimethylsilyl cyanide to the ketimines efficiently provides a direct entry to both enantiomers of pyrazolone α- aminonitrile derivatives at will in good yields and high enantioselectivities for a wide variety of substrates.

Julkaisija

Royal Society of Chemistry

ISSN Hae Julkaisufoorumista

1359-7345

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