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dc.contributor.authorRonkainen, Paula
dc.contributor.authorLaakkonen, Eija
dc.contributor.authorTörmäkangas, Timo
dc.contributor.authorTiainen, Kristina
dc.contributor.authorKoskenvuo, Markku
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorRantanen, Taina
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorKovanen, Vuokko
dc.date.accessioned2017-05-11T09:52:24Z
dc.date.available2017-05-11T09:52:24Z
dc.date.issued2008
dc.identifier.citationRonkainen, P., Laakkonen, E., Törmäkangas, T., Tiainen, K., Koskenvuo, M., Kaprio, J., Rantanen, T., Sipilä, S., & Kovanen, V. (2008). Catechol-O-Methyltransferase Gene Polymorphism Is Associated with Skeletal Muscle Properties in Older Women Alone and Together with Physical Activity. <i>PLoS ONE</i>, <i>3</i>(3). <a href="https://doi.org/10.1371/journal.pone.0001819" target="_blank">https://doi.org/10.1371/journal.pone.0001819</a>
dc.identifier.otherCONVID_17763655
dc.identifier.otherTUTKAID_30421
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/53896
dc.description.abstractBackground Muscle strength declines on average by one percent annually from midlife on. In postmenopausal women this decrement coincides with a rapid decline in estrogen production. The genetics underlying the effects of estrogen on skeletal muscle remains unclear. In the present study, we examined whether polymorphisms within COMT and ESR1 are associated with muscle properties and assessed their interaction and their combined effects with physical activity. Methodology/Principal Findings A cross-sectional data analysis was conducted with 434 63-76-year-old women from the population-based Finnish Twin Study on Aging. Body anthropometry, muscle cross-sectional area (mCSA), isometric hand grip and knee extension strengths, and leg extension power were measured. COMT Val158Met and ESR1 PvuII genotypes were determined by the RFLP method. mCSA differed by COMT genotypes (p = 0.014) being significantly larger in LL than HL individuals in unadjusted (p = 0.001) and age- and height-adjusted model (p = 0.004). When physical activity and age were entered into GEE model, COMT genotype had a significant main effect (p = 0.038) on mCSA. Furthermore, sedentary individuals with the HH genotype had lower muscle mass, strength and power, but they also appeared to benefit the most from physical activity. No association of ESR1 PvuII polymorphism with any of the muscle outcomes was observed. Conclusions/Significance The present study suggests that the COMT polymorphism, affecting the activity of the enzyme, is associated with muscle mass. Furthermore, sedentary individuals with potential high enzyme activity were the weakest group, but they may potentially benefit the most from physical activity. This observation elucidates the importance of both environmental and genetic factors in muscle properties.
dc.language.isoeng
dc.publisherPLoS ONE
dc.relation.ispartofseriesPLoS ONE
dc.subject.otherCOMT
dc.subject.otherESR1 ja luurankolihas
dc.subject.otherESR1 and Skeletal Muscle
dc.titleCatechol-O-Methyltransferase Gene Polymorphism Is Associated with Skeletal Muscle Properties in Older Women Alone and Together with Physical Activity
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201705082230
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-05-08T12:15:15Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.numberinseries3
dc.relation.volume3
dc.type.versionpublishedVersion
dc.rights.copyright© 2008 Ronkainen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1371/journal.pone.0001819


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© 2008 Ronkainen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
Except where otherwise noted, this item's license is described as © 2008 Ronkainen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.