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dc.contributor.authorKronholm, Ilkka
dc.contributor.authorJohannesson, Hanna
dc.contributor.authorKetola, Tarmo
dc.date.accessioned2016-12-13T07:54:27Z
dc.date.available2016-12-13T07:54:27Z
dc.date.issued2016
dc.identifier.citationKronholm, I., Johannesson, H., & Ketola, T. (2016). Epigenetic Control of Phenotypic Plasticity in the Filamentous Fungus Neurospora crassa. <i>G3: Genes, Genomes, Genetics</i>, <i>6</i>(12), 4009-4022. <a href="https://doi.org/10.1534/g3.116.033860" target="_blank">https://doi.org/10.1534/g3.116.033860</a>
dc.identifier.otherCONVID_26250173
dc.identifier.otherTUTKAID_71369
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/52284
dc.description.abstractPhenotypic plasticity is the ability of a genotype to produce different phenotypes under different environmental or developmental conditions. Phenotypic plasticity is a ubiquitous feature of living organisms, and is typically based on variable patterns of gene expression. However, the mechanisms by which gene expression is influenced and regulated during plastic responses are poorly understood in most organisms. While modifications to DNA and histone proteins have been implicated as likely candidates for generating and regulating phenotypic plasticity, specific details of each modification and its mode of operation have remained largely unknown. In this study, we investigated how epigenetic mechanisms affect phenotypic plasticity in the filamentous fungus Neurospora crassa. By measuring reaction norms of strains that are deficient in one of several key physiological processes, we show that epigenetic mechanisms play a role in homeostasis and phenotypic plasticity of the fungus across a range of controlled environments. In general, effects on plasticity are specific to an environment and mechanism, indicating that epigenetic regulation is context dependent and is not governed by general plasticity genes. Specifically, we found that, in Neurospora, histone methylation at H3K36 affected plastic response to high temperatures, H3K4 methylation affected plastic response to pH, but H3K27 methylation had no effect. Similarly, DNA methylation had only a small effect in response to sucrose. Histone deacetylation mainly decreased reaction norm elevation, as did genes involved in histone demethylation and acetylation. In contrast, the RNA interference pathway was involved in plastic responses to multiple environments.
dc.language.isoeng
dc.publisherGenetics Society of America
dc.relation.ispartofseriesG3: Genes, Genomes, Genetics
dc.subject.otherreaction norm
dc.subject.otherHistone methylation
dc.subject.otherHistone deacetylation
dc.titleEpigenetic Control of Phenotypic Plasticity in the Filamentous Fungus Neurospora crassa
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201612125034
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.contributor.oppiaineBiologisten vuorovaikutusten huippututkimusyksikköfi
dc.contributor.oppiaineEcology and Evolutionary Biologyen
dc.contributor.oppiaineCentre of Excellence in Biological Interactions Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-12-12T07:15:07Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange4009-4022
dc.relation.issn2160-1836
dc.relation.numberinseries12
dc.relation.volume6
dc.type.versionpublishedVersion
dc.rights.copyright© 2016 Kronholm et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License.
dc.rights.accesslevelopenAccessfi
dc.subject.ysosienet
dc.subject.ysoDNA-metylaatio
dc.subject.ysoRNA-interferenssi
jyx.subject.urihttp://www.yso.fi/onto/yso/p90
jyx.subject.urihttp://www.yso.fi/onto/yso/p38350
jyx.subject.urihttp://www.yso.fi/onto/yso/p38816
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1534/g3.116.033860


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© 2016 Kronholm et al. This is an open-access article distributed under the terms of the Creative
Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as © 2016 Kronholm et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License.