Näytä suppeat kuvailutiedot

dc.contributor.authorWaller, Katja
dc.contributor.authorKaprio, J.
dc.contributor.authorKorhonen, T.
dc.contributor.authorTuulio-Henriksson, A.
dc.contributor.authorKujala, Urho
dc.date.accessioned2016-05-09T06:04:10Z
dc.date.available2017-04-20T21:45:05Z
dc.date.issued2016
dc.identifier.citationWaller, K., Kaprio, J., Korhonen, T., Tuulio-Henriksson, A., & Kujala, U. (2016). Persistent leisure-time physical activity in adulthood and use of antidepressants : a follow-up study among twins. <i>Journal of Affective Disorders</i>, <i>200</i>(August), 172-177. <a href="https://doi.org/10.1016/j.jad.2016.04.036" target="_blank">https://doi.org/10.1016/j.jad.2016.04.036</a>
dc.identifier.otherCONVID_25669157
dc.identifier.otherTUTKAID_69838
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/49661
dc.description.abstractBackground To study whether persistent leisure-time physical activity (PA) during adulthood predicts use of antidepressants later in life. Methods The Finnish Twin Cohort comprises same-sex twin pairs born before 1958, of whom 11 325 individuals answered PA questions in 1975, 1981 and 1990 at a mean age of 44 years (range 33–60). PA volume over 15-years was used as the predictor of subsequent use of antidepressants. Antidepressant use (measured as number of purchases) for 1995–2004 were collected from the Finnish Social Insurance Institution (KELA) prescription register. Conditional logistic regression was conducted to calculate odds ratios (OR) with 95% confidence intervals (CI) for the use of antidepressants in pairs discordant for PA (642, including 164 monozygotic (MZ) pairs). Results Altogether 229 persons had used at least one prescribed antidepressant during the study period. Active co-twins had a lower risk (unadjusted OR 0.80, 95%CI 0.67–0.95) for using any amount of antidepressants than their inactive co-twins; trends being similar for DZ (0.80, 0.67–0.97) and MZ pairs (0.78, 0.51–1.17). The lowest odds ratio (0.51, 0.26–0.98) was seen among MZ pairs after adjusting for BMI, smoking and binge drinking. The point estimates were similar but non-significant for long-term antidepressant use (4+purchases equivalent to 12 months use). Limitations Self-reported physical activity and low number of discordant MZ pairs. Discussion Use of antidepressants was less common among physically active co-twins even when shared childhood experiences and genetic background were controlled for. Physical activity in midlife may therefore be important in preventing mild depression later in life.
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofseriesJournal of Affective Disorders
dc.subject.otherphysical activity
dc.subject.otherdepression
dc.subject.otherantidepressants
dc.subject.othergenetic
dc.subject.otherfollow-up
dc.titlePersistent leisure-time physical activity in adulthood and use of antidepressants : a follow-up study among twins
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201605042426
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-05-04T09:15:12Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange172-177
dc.relation.issn0165-0327
dc.relation.numberinseriesAugust
dc.relation.volume200
dc.type.versionacceptedVersion
dc.rights.copyright© 2016 Elsevier B.V. This is a final draft version of an article whose final and definitive form has been published by Elsevier. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.subject.ysojoutilaisuus
dc.subject.ysokaksoset
jyx.subject.urihttp://www.yso.fi/onto/yso/p8123
jyx.subject.urihttp://www.yso.fi/onto/yso/p9845
dc.relation.doi10.1016/j.jad.2016.04.036
dc.type.okmA1


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