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dc.contributor.authorPekkala, Satu
dc.contributor.authorWiklund, Petri
dc.contributor.authorHulmi, Juha
dc.contributor.authorAhtiainen, Juha
dc.contributor.authorHorttanainen, Mia
dc.contributor.authorLaakkonen, Eija
dc.contributor.authorMäkelä, Kari
dc.contributor.authorKainulainen, Heikki
dc.contributor.authorHäkkinen, Keijo
dc.contributor.authorNyman, Kai
dc.contributor.authorAlén, Markku
dc.contributor.authorHerzig, Karl-Heinz
dc.contributor.authorCheng, Sulin
dc.date.accessioned2016-03-17T06:47:40Z
dc.date.available2016-03-17T06:47:40Z
dc.date.issued2013
dc.identifier.citationPekkala, S., Wiklund, P., Hulmi, J., Ahtiainen, J., Horttanainen, M., Laakkonen, E., Mäkelä, K., Kainulainen, H., Häkkinen, K., Nyman, K., Alén, M., Herzig, K.-H., & Cheng, S. (2013). Are skeletal muscle FNDC5 expression and irisin release regulated by exercise and related to health?. <i>Journal of Physiology</i>, <i>591</i>(21), 5393-5400. <a href="https://doi.org/10.1113/jphysiol.2013.263707" target="_blank">https://doi.org/10.1113/jphysiol.2013.263707</a>
dc.identifier.otherCONVID_23013748
dc.identifier.otherTUTKAID_59252
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/49089
dc.description.abstractRecently, contradictory findings have been reported concerning the function of irisin and its precursor gene, skeletal muscle FNDC5, in energy homeostasis, and the associated regulatory role of exercise and PGC-1α. We therefore evaluated whether muscle FNDC5 mRNA and serum irisin are exercise responsive and whether PGC-1α expression is associated with FNDC5 expression. The male subjects in the study performed single exercises: (1) 1 h low-intensity aerobic exercise (AE) (middle-aged, n= 17), (2) a heavy-intensity resistance exercise (RE) bout (young n= 10, older n= 11) (27 vs. 62 years), (3) long-term 21 weeks endurance exercise (EE) training alone (twice a week, middle-aged, n= 9), or (4) combined EE and RE training (both twice a week, middle-aged, n= 9). Skeletal muscle mRNA expression was analysed by quantitative PCR and serum irisin by ELISA. No significant changes were observed in skeletal muscle PGC-1α, FNDC5 and serum irisin after AE, EE training or combined EE + RE training. However, a single RE bout increased PGC-1α by 4-fold in young and by 2-fold in older men, while FNDC5 mRNA only increased in young men post-RE, by 1.4-fold. Changes in PGC-1α or serum irisin were not consistently accompanied by changes in FNDC5. In conclusion, for the most part, neither longer-term nor single exercise markedly increases skeletal muscle FNDC5 expression or serum irisin. Therefore their changes in response to exercise are probably random and not consistent excluding the confirmation of any definitive link between exercise and FNDC5 expression and irisin release in humans. Moreover, irisin and FNDC5 were not associated with glucose tolerance and being overweight, or with metabolic disturbances, respectively. Finally, factor(s) other than PGC-1α and transcription may regulate FNDC5 expression.
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofseriesJournal of Physiology
dc.subject.otherluurankolihas
dc.subject.otheririsiini
dc.subject.otherskeletal muscle
dc.subject.otherexercise
dc.subject.otheririsin
dc.titleAre skeletal muscle FNDC5 expression and irisin release regulated by exercise and related to health?
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201603161860
dc.contributor.laitosLiikuntabiologian laitosfi
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Biology of Physical Activityen
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-03-16T13:15:07Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange5393-5400
dc.relation.issn0022-3751
dc.relation.numberinseries21
dc.relation.volume591
dc.type.versionpublishedVersion
dc.rights.copyright© 2013 The Authors. The Journal of Physiology © 2013 The Physiological Society. Published by Wiley-Blackwell.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoliikunta
jyx.subject.urihttp://www.yso.fi/onto/yso/p916
dc.relation.doi10.1113/jphysiol.2013.263707


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