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dc.contributor.authorEkengard, Erik
dc.contributor.authorKumar, Kamlesh
dc.contributor.authorFogeron, Thibault
dc.contributor.authorKock, Carmen de
dc.contributor.authorSmith, Peter J.
dc.contributor.authorHaukka, Matti
dc.contributor.authorMonari, Magda
dc.contributor.authorNordlander, Ebbe
dc.date.accessioned2016-03-16T08:15:34Z
dc.date.available2016-03-16T08:15:34Z
dc.date.issued2016
dc.identifier.citationEkengard, E., Kumar, K., Fogeron, T., Kock, C. D., Smith, P. J., Haukka, M., Monari, M., & Nordlander, E. (2016). Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization and antimalarial properties. <i>Dalton Transactions</i>, <i>45</i>(9), 3905-3917. <a href="https://doi.org/10.1039/C5DT03739E" target="_blank">https://doi.org/10.1039/C5DT03739E</a>
dc.identifier.otherCONVID_25595914
dc.identifier.otherTUTKAID_69445
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/49067
dc.description.abstractThe synthesis and characterization of twenty new pentamethylcyclopentadienyl-rhodium and iridium complexes containing N^N and N^O-chelating chloroquine analogue ligands are described. The in vitro antimalarial activity of the new ligands as well as the complexes was evaluated against the chloroquine sensitive (CQS) NF54 and the chloroquine resistant (CQR) Dd2 strains of Plasmodium falciparum. The antimalarial activity was found to be good to moderate; although all complexes are less active than artesunate, some of the ligands and complexes showed better activity than chloroquine (CQ). In particular, rhodium complexes were found to be considerably more active than iridium complexes against the CQS NF54 strain. Salicylaldimine Schiff base ligands having electron-withdrawing groups (F, Cl, Br, I and NO2) in para position of the salicyl moiety and their rhodium complexes showed good antiplasmodial activity against both the CQS-NF54 and the CQR-Dd2 strains. The crystal structures of (η5-pentamethylcyclopentadienyl){N1-(7-chloroquinolin-4-yl)-N2-(pyridin-2-ylmethyl)ethane-1,2-diamine)} chlororhodium(III) chloride and (η5-pentamethylcyclopentadienyl){(4-chloro-2-(((2-((7-chloroquinolin-4-yl)amino)ethyl)imino)methyl)phenolate)}chlororhodium(III) chloride are reported. The crystallization of the amino-pyridyl complex (η5-pentamethylcyclopentadienyl){(N1-(7-chloroquinolin-4-yl)-N2-(pyridin-2-ylmethyl)ethane-1,2-diamine)}chloroiridium(III) chloride in acetone resulted in the formation of the imino-pyridyl derivative (η5-pentamethylcyclopentadienyl){(N1-(7-chloroquinolin-4-yl)-N2-(pyridin-2-ylmethylene)ethane-1,2-diamine)}chloroiridium(III) chloride, the crystal structure of which is also reported.
dc.language.isoeng
dc.publisherRSC Publications
dc.relation.ispartofseriesDalton Transactions
dc.subject.otherpentamethylcyclopentadienyl-rhodium complexes
dc.subject.otheriridium complexes
dc.subject.otherchloroquine analogue ligands
dc.subject.otherantimalarial properties
dc.titlePentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization and antimalarial properties
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201603141837
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineEpäorgaaninen ja analyyttinen kemiafi
dc.contributor.oppiaineInorganic and Analytical Chemistryen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-03-14T10:15:05Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange3905-3917
dc.relation.issn1477-9226
dc.relation.numberinseries9
dc.relation.volume45
dc.type.versionpublishedVersion
dc.rights.copyright© 2016 the Authors. This is an open access article licensed under a Creative Commons Attribution 3.0 Unported Licence.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttp://creativecommons.org/licenses/by/3.0/
dc.relation.doi10.1039/C5DT03739E


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© 2016 the Authors. This is an open access article licensed under a Creative Commons Attribution 3.0 Unported Licence.
Except where otherwise noted, this item's license is described as © 2016 the Authors. This is an open access article licensed under a Creative Commons Attribution 3.0 Unported Licence.