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dc.contributor.authorJulkunen, Petro
dc.contributor.authorKönönen, Mervi
dc.contributor.authorMäättä, Sara
dc.contributor.authorTarkka, Ina
dc.contributor.authorHiekkala, Sinikka H.
dc.contributor.authorSäisänen, Laura
dc.contributor.authorVanninen, Ritva
dc.contributor.authorKarhu, Jari
dc.contributor.authorJäkälä, Pekka
dc.date.accessioned2016-02-29T08:39:23Z
dc.date.available2017-02-09T22:45:05Z
dc.date.issued2016
dc.identifier.citationJulkunen, P., Könönen, M., Määttä, S., Tarkka, I., Hiekkala, S. H., Säisänen, L., . . . Jäkälä, P. (2016). Longitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke. <em>Neuroscience Letters</em>, 617, 88-93. <a href="http://dx.doi.org/10.1016/j.neulet.2016.02.014">doi:10.1016/j.neulet.2016.02.014</a>
dc.identifier.otherTUTKAID_69090
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/48957
dc.description.abstractCorticospinal excitability (CSE) is modulated by stroke-induced lesions affecting the brain. This modulation is known to be dependent on the timing of the evaluation, and strongest abnormalities are often found in the acute stage. Our study aimed to characterize changes in CSE asymmetry between the affected and the unaffected hemisphere (AH and UH) during the first month after stroke onset and at 6 month follow-up. Neuronavigated transcranial magnetic stimulation (nTMS) was used to assess the CSE of the abductor pollicis brevis (APB) muscle of the hand and tibialis anterior (TA) muscle of the leg in 16 patients over 5 time-points. AH excitability recovered significantly during 6 months, whereas interhemispheric asymmetry remained significant up to 1 month post-stroke in the APB muscle. Greater initial CSE was associated with good motor function at 6 months. The motor cortical excitatory recovery initiated within week of the stroke and was most prominent within 1 month after stroke onset. Lesion size correlated with CSE of the UH at 10 days, while overall severity of the symptoms correlated inversely with CSE of the AH. This study demonstrates the quick improvement in the CSE via estimation of interhemispheric asymmetry; however, the recovery in the asymmetry continues to normalize even after reaching the threshold for normal values in CSE.
dc.language.isoeng
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofseriesNeuroscience Letters
dc.subject.othercorticospinal excitability
dc.subject.othermotor evoked potential
dc.subject.othertranscranial magnetic stimulation
dc.subject.othermotor threshold
dc.subject.otherstroke
dc.titleLongitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201602241682
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiede
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-02-24T13:15:09Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange88-93
dc.relation.issn0304-3940
dc.relation.volume617
dc.type.versionacceptedVersion
dc.rights.copyright© 2016 Elsevier Ireland Ltd. This is a final draft version of an article whose final and definitive form has been published by Elsevier. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.relation.doi10.1016/j.neulet.2016.02.014


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