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dc.contributor.authorHelttunen, Kaisa
dc.contributor.authorGalán, Albano
dc.contributor.authorBallester, Pablo
dc.contributor.authorBergenholtz, Johan
dc.contributor.authorNissinen, Maija
dc.date.accessioned2016-02-23T06:43:30Z
dc.date.available2017-11-10T22:45:04Z
dc.date.issued2016
dc.identifier.citationHelttunen, K., Galán, A., Ballester, P., Bergenholtz, J., & Nissinen, M. (2016). Solid lipid nanoparticles from amphiphilic calixpyrroles. <em>Journal of Colloid and Interface Science</em>, 464 (February), 59-65. <a href="http://dx.doi.org/10.1016/j.jcis.2015.11.012">doi:10.1016/j.jcis.2015.11.012</a>
dc.identifier.otherTUTKAID_67953
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/48888
dc.description.abstractHypothesis Macrocyclic amphiphiles form interesting self-assembling structures, including solid lipid nanoparticles, which have potential applications in drug encapsulation. Aryl-extended calixpyrroles, which act as anion binding hosts, are expected to form solid lipid nanoparticles, even though the alkyl chains have unusual perpendicular geometry with respect to the hydrophilic head group. The preparation conditions and the alkyl chain length should affect the size and stability of the particles. Experiments Solid lipid nanoparticles of two aryl-extended calixpyrroles with resorcinol walls and either meso-dodecyl or meso-methyl alkyl chains were compared. Ethanolic solutions of the calixpyrroles were mixed with water and the resulting nanoparticle dispersions were studied with dynamic light scattering and nanoparticle tracking analysis. The effect of different calixpyrrole/ethanol/water ratios on particle size was tested. The surface charge of the particles at different pH and NaCl concentration was determined by zeta potential measurements. Findings The meso-dodecyl calixpyrrole produced small nanoparticles with mean hydrodynamic diameters between 40 and 70 nm in 0.86–4.28 M ethanol. The particles were stable in solution for several months. Particles prepared from meso-methyl calixpyrrole were larger and less stable. The smallest particles were obtained with low calixpyrrole concentration and calixpyrrole/ethanol ratio. Larger ethanol/water ratio induced broader particle size distributions. Increasing pH aided the stability of the particles due to increased negative surface charge.
dc.language.isoeng
dc.publisherElsevier Inc.
dc.relation.ispartofseriesJournal of Colloid and Interface Science
dc.subject.otheramphiphile
dc.subject.othercalixpyrrole
dc.subject.otherdynamic light scattering
dc.subject.othermacrocycle
dc.subject.othernanoparticle tracking analysis
dc.subject.othersolid lipid nanoparticle
dc.subject.otherzeta potential
dc.titleSolid lipid nanoparticles from amphiphilic calixpyrroles
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201602221641
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-02-22T10:15:07Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange59-65
dc.relation.issn0021-9797
dc.relation.volume464
dc.type.versionacceptedVersion
dc.rights.copyright© 2015 Elsevier Inc. This is a final draft version of an article whose final and definitive form has been published by Elsevier. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.relation.doi10.1016/j.jcis.2015.11.012


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