Distribution and dynamics of transcription-associated proteins during parvovirus infection.
Ihalainen, T., Willman, S., Niskanen, E., Paloheimo, O., Smolander, H., Laurila, J., . . . , & Vihinen-Ranta, M. (2012). Distribution and dynamics of transcription-associated proteins during parvovirus infection. Journal Of Virology, 86 (24), 13779-84. doi:10.1128/JVI.01625-12
Published inJournal Of Virology
DisciplineSolu- ja molekyylibiologia
© 2012, American Society for Microbiology. Published in this repository with the kind permission of the publisher.
Canine parvovirus (CPV) infection leads to reorganization of nuclear proteinaceous subcompartments. Our studies showed that virus infection causes a time-dependent increase in the amount of viral nonstructural protein NS1 mRNA. Fluorescence recovery after photobleaching showed that the recovery kinetics of nuclear transcription-associated proteins, TATA binding protein (TBP), transcription factor IIB (TFIIB), and poly(A) binding protein nuclear 1 (PABPN1) were different in infected and noninfected cells, pointing to virus-induced alterations in binding dynamics of these proteins.