Role of mitochondria in parvovirus pathology
Nykky, J., Vuento, M., & Gilbert, L. (2014). Role of mitochondria in parvovirus pathology. PLoS ONE, 9(1), Article e86124. https://doi.org/10.1371/journal.pone.0086124
Published inPLoS ONE
© 2014 Nykky et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Proper functioning of the mitochondria is crucial for the survival of the cell. Viruses are able to interfere with mitochondrial functions as they infect the host cell. Parvoviruses are known to induce apoptosis in infected cells, but the role of the mitochondria in parvovirus induced cytopathy is only partially known. Here we demonstrate with confocal and electron microscopy that canine parvovirus (CPV) associated with the mitochondrial outer membrane from the onset of infection. During viral entry a transient depolarization of the mitochondrial transmembrane potential and increase in ROS level was detected. Subsequently, mitochondrial homeostasis was normalized shortly, as detected by repolarization of the mitochondrial membrane and decrease of ROS. Indeed, activation of cell survival signalling through ERK1/2 cascade was observed early in CPV infected cells. At 12 hours post infection, concurrent with the expression of viral non-structural protein 1, damage to the mitochondrial structure and depolarization of its membrane were apparent. Results of this study provide additional insight of parvovirus pathology and also more general information of virus-mitochondria association. ...
PublisherPublic Library of Science
ISSN Search the Publication Forum1932-6203
Publication in research information system
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Except where otherwise noted, this item's license is described as © 2014 Nykky et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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