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dc.contributor.authorCheung, Stephen S.
dc.contributor.authorMutanen, Niina E.
dc.contributor.authorKarinen, Heikki M.
dc.contributor.authorKoponen, Anne S.
dc.contributor.authorKyröläinen, Heikki
dc.contributor.authorTikkanen, Heikki O.
dc.contributor.authorPeltonen, Juha E.
dc.date.accessioned2014-09-30T08:54:41Z
dc.date.available2014-09-30T08:54:41Z
dc.date.issued2014
dc.identifier.citationCheung, S. S., Mutanen, N. E., Karinen, H. M., Koponen, A. S., Kyröläinen, H., Tikkanen, H. O., & Peltonen, J. E. (2014). Ventilatory Chemosensitivity, Cerebral and Muscle Oxygenation, and Total Hemoglobin Mass Before and After a 72-Day Mt. Everest Expedition. <i>High Altitude Medicine and Biology</i>, <i>15</i>(3), 331-340. <a href="https://doi.org/10.1089/ham.2013.1153" target="_blank">https://doi.org/10.1089/ham.2013.1153</a>
dc.identifier.otherCONVID_23866054
dc.identifier.otherTUTKAID_62963
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/44355
dc.description.abstractAbstract. Cheung, Stephen S, Niina E. Mutanen, Heikki M. Karinen, Anne S. Koponen, Heikki Kyro ̈ la ̈ inen, Heikki O. Tikkanen, and Juha E. Peltonen. Ventilatory chemosensitivity, cerebral and muscle oxygenation, and total hemoglobin mass before and after a 72-day Mt. Everest expedition. High Alt Med Biol 15:331–340, 2014.— Background: We investigated the effects of chronic hypobaric hypoxic acclimatization, performed over the course of a 72-day self-supported Everest expedition, on ventilatory chemosensitivity, arterial saturation, and tissue oxygenation adaptation along with total hemoglobin mass (tHb-mass) in nine experienced climbers (age 37 – 6 years, _ VO 2peak 55 – 7mL $ kg - 1 $ min - 1 ). Methods: Exercise-hypoxia tolerance was tested using a constant treadmill exercise of 5.5 km $ h - 1 at 3.8% grade (mimicking exertion at altitude) with 3-min steps of progressive normobaric poikilocapnic hypoxia. Breath-by-breath ventilatory responses, Sp o 2 , and cerebral (frontal cortex) and active muscle (vastus lateralis) oxygenation were measured throughout. Acute hypoxic ventilatory response (AHVR) was determined by linear regression slope of ventilation vs. Sp o 2 . PRE and POST ( < 15 days) expedition, tHb-mass was measured using carbon monoxide-rebreathing. Results: Post-expedition, exercise-hypoxia tolerance improved (11:32 – 3:57 to 16:30 – 2:09 min, p < 0.01). AHVR was elevated (1.25 – 0.33 to 1.63 – 0.38 L $ min - 1. % - 1 Sp o 2 , p < 0.05). Sp o 2 decreased throughout exercise-hypoxia in both trials, but was preserved at higher values at 4800 m post-expedition. Cerebral oxygenation decreased progressively with increasing exercise-hypoxia in both trials, with a lower level of deoxyhemoglobin POST at 2400, 3500 and 4800 m. Muscle oxygenation also decreased throughout exercise- hypoxia, with similar patterns PRE and POST. No relationship was observed between the slope of AHVR and cerebral or muscle oxygenation either PRE or POST. Absolute tHb-mass response exhibited great individual variation with a nonsignificant 5.4% increasing trend post-expedition (975 – 154 g PRE and 1025 – 124 g POST, p = 0.17). Conclusions: We conclude that adaptation to chronic hypoxia during a climbing expedition to Mt. Everest will increase hypoxic tolerance, AHVR, and cerebral but not muscle oxygenation, as measured during simulated acute hypoxia at sea level. However, tHb-mass did not increase significantly and improvement in cerebral oxygenation was not associated with the change in AHVRfi
dc.languageeng
dc.language.isoeng
dc.publisherMary AnnLiebert, Inc. Publishers; International Society for Mountain Medicine
dc.relation.ispartofseriesHigh Altitude Medicine and Biology
dc.subject.otheracute hypoxic ventilatory response
dc.subject.otheraltitude adaptation
dc.subject.otherchronic hypoxia
dc.subject.otherclimbers
dc.subject.otherextreme altitude
dc.subject.otherNIRS
dc.titleVentilatory Chemosensitivity, Cerebral and Muscle Oxygenation, and Total Hemoglobin Mass Before and After a 72-Day Mt. Everest Expedition
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201409302904
dc.contributor.laitosLiikuntabiologian laitosfi
dc.contributor.laitosDepartment of Biology of Physical Activityen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineExercise Physiologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2014-09-30T03:30:25Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange331-340
dc.relation.issn1527-0297
dc.relation.numberinseries3
dc.relation.volume15
dc.type.versionpublishedVersion
dc.rights.copyright© Mary Ann Liebert, Inc.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttp://www.liebertpub.com/archpolicy/journal-of-womens-health/42/
dc.relation.doi10.1089/ham.2013.1153
dc.type.okmA1


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