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• Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, part 1 – Transcriptomics 

  Rigaud, Cyril; Eriksson, Andreas; Krasnov, Aleksei; Wincent, Emma; Pakkanen, Hannu; Lehtivuori, Heli; Ihalainen, Janne; Vehniäinen, Eeva-Riikka (Elsevier BV, 2020)

  Polycyclic aromatic hydrocarbons (PAHs) are contaminants of concern that impact every sphere of the environment. Despite several decades of research, their mechanisms of toxicity are still poorly understood. This study ...

• Exposure to retene, fluoranthene, and their binary mixture causes distinct transcriptomic and apical outcomes in rainbow trout (Oncorhynchus mykiss) yolk sac alevins 

  Eriksson, Andreas N.M.; Rigaud, Cyril; Krasnov, Aleksei; Wincent, Emma; Vehniäinen, Eeva-Riikka (Elsevier, 2022)

  Polycyclic aromatic hydrocarbons (PAHs) are widely spread environmental contaminants which affect developing organisms. It is known that improper activation of the aryl hydrocarbon receptor (AhR) by some PAHs contributes ...

• Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, Part 2 – Proteomics and metabolomics 

  Rigaud, Cyril; Eriksson, Andreas; Rokka, Anne; Skaugen, Morten; Lihavainen, Jenna; Keinänen, Markku; Lehtivuori, Heli; Vehniäinen, Eeva-Riikka (Elsevier BV, 2020)

  Polycyclic aromatic hydrocarbons (PAHs) are global contaminants of concern. Despite several decades of research, their mechanisms of toxicity are not very well understood. Early life stages of fish are particularly sensitive ...

• An unclosing jaw as a symptom of PAH exposure in rainbow trout yolk sac larvae 

  Leinonen, Anni (2023)

  Fenantreeni (PHE) ja fluoranteeni (FLA), kaksi polysyklistä aromaattista hiilivety-yhdistettä (PAH), ovat yleisesti vesistöissä esiintyviä vierasaineita ja myrkyllisiä kalojen varhaisille kehitysvaiheille. Tässä tutkimuksessa ...

• Endogenous AhR agonist FICZ accumulates in rainbow trout (Oncorhynchus mykiss) alevins exposed to a mixture of two PAHs, retene and fluoranthene 

  Eriksson, Andreas N. M.; Rigaud, Cyril; Wincent, Emma; Pakkanen, Hannu; Salonen, Pihla; Vehniäinen, Eeva-Riikka (Springer, 2022)

  Multiple studies have reported synergized toxicity of PAH mixtures in developing fish larvae relative to the additive effect of the components. From a toxicological perspective, multiple mechanisms are known to contribute ...