Näytä suppeat kuvailutiedot

dc.contributor.authorMa, Hongqiang
dc.contributor.authorTurpeinen, Tuomas
dc.contributor.authorSilvennoinen, Mika
dc.contributor.authorTorvinen, Sira
dc.contributor.authorRinnankoski-Tuikka, Rita
dc.contributor.authorKainulainen, Heikki
dc.contributor.authorTimonen, Jussi
dc.contributor.authorKujala, Urho M.
dc.contributor.authorRahkila, Paavo
dc.contributor.authorSuominen, Harri
dc.date.accessioned2011-05-13T08:12:34Z
dc.date.available2011-05-13T08:12:34Z
dc.date.issued2011
dc.identifier.citationMa, H., Turpeinen, T., Silvennoinen, M., Torvinen, S., Rinnankoski-Tuikka, R., Kainulainen, H., Timonen, J., Kujala, U., Rahkila, P. & Suominen, H. (2011). Effects of diet-induced obesity and voluntary wheel running on the microstructure of the murine distal femur. Nutrition & Metabolism, 8:1. Retrieved from http://www.nutritionandmetabolism.com/content/8/1/1
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/26963
dc.description.abstractBackground. Obesity and osteoporosis, two possibly related conditions, are rapidly expanding health concerns in modern society. Both of them are associated with sedentary life style and nutrition. To investigate the effects of diet-induced obesity and voluntary physical activity we used high resolution micro-computed tomography (μCT) together with peripheral quantitative computed tomography (pQCT) to examine the microstructure of the distal femoral metaphysis in mice. Methods. Forty 7-week-old male C57BL/6J mice were assigned to 4 groups: control (C), control + running (CR), high-fat diet (HF), and high-fat diet + running (HFR). After a 21-week intervention, all the mice were sacrificed and the left femur dissected for pQCT and μCT measurements. Results. The mice fed the high-fat diet showed a significant weight gain (over 70% for HF and 60% for HFR), with increased epididymal fat pad mass and impaired insulin sensitivity. These obese mice had significantly higher trabecular connectivity density, volume, number, thickness, area and mass, and smaller trabecular separation. At the whole bone level, they had larger bone circumference and cross-sectional area and higher density-weighted maximal, minimal, and polar moments of inertia. Voluntary wheel running decreased all the cortical bone parameters, but increased the trabecular mineral density, and decreased the pattern factor and structure model index towards a more plate-like structure. Conclusions. The results suggest that in mice the femur adapts to obesity by improving bone strength both at the whole bone and micro-structural level. Adaptation to running exercise manifests itself in increased trabecular density and improved 3D structure, but in a limited overall bone growthen
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofseriesNutrition & Metabolism
dc.titleEffects of diet-induced obesity and voluntary wheel running on the microstructure of the murine distal femur
dc.typeArticle
dc.identifier.urnURN:NBN:fi:jyu-2011051310802
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.identifier.doidoi:10.1186/1743-7075-8-1
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn1743-7075
dc.type.versionpublishedVersion
dc.rights.copyright© 2011 Ma et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttp://creativecommons.org/licenses/by/2


Aineistoon kuuluvat tiedostot

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Aineisto kuuluu seuraaviin kokoelmiin

Näytä suppeat kuvailutiedot

© 2011 Ma et al; licensee BioMed Central Ltd. 


This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Ellei muuten mainita, aineiston lisenssi on © 2011 Ma et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.