Activities of angiotensin-converting enzymes (ACE1, ACE2) and inhibition by bioactive lactotripeptides (IPP, VPP, LPP) in porcine ocular tissues
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Toxicological and bioactivity evaluation of blackcurrant press cake, sea buckthorn leaves and bark from Scots pine and Norway spruce extracts under a green integrated approach
Pap, Nora; Reshamwala, Dhanik; Korpinen, Risto; Kilpeläinen, Petri; Fidelis, Marina; Furtado, Marianna M.; Sant’Ana, Anderson S.; Wen, Mingchun; Zhang, Liang; Hellström, Jarkko; Marnilla, Pertti; Mattila, Pirjo; Sarjala, Tytti; Yang, Baoru; dos Santos Lima, Amanda; Azevedo, Luciana; Marjomäki, Varpu; Granato, Daniel (Elsevier, 2021)Aqueous extracts from blackcurrant press cake (BC), Norway spruce bark (NS), Scots pine bark (SP), and sea buckthorn leaves (SB) were obtained using maceration and pressurized hot water and tested for their bioactivities. ... -
Salix spp. Bark Hot Water Extracts Show Antiviral, Antibacterial, and Antioxidant Activities : The Bioactive Properties of 16 Clones
Tienaho, Jenni; Reshamwala, Dhanik; Sarjala, Tytti; Kilpeläinen, Petri; Liimatainen, Jaana; Dou, Jinze; Viherä-Aarnio, Anneli; Linnakoski, Riikka; Marjomäki, Varpu; Jyske, Tuula (Frontiers Media SA, 2021)Earlier studies have shown that the bark of Salix L. species (Salicaceae family) is rich in extractives, such as diverse bioactive phenolic compounds. However, we lack knowledge on the bioactive properties of the bark of ... -
Construction of Spirooxindole Analogues Engrafted with Indole and Pyrazole Scaffolds as Acetylcholinesterase Inhibitors
Islam, Mohammad Shahidul; Al-Majid, Abdullah Mohammed; Azam, Mohammad; Verma, Ved Prakash; Barakat, Assem; Haukka, Matti; Elgazar, Abdullah A.; Mira, Amira; Badria, Farid A. (American Chemical Society (ACS), 2021)Twenty-five new hits of spirooxindole analogs 8a–y engrafted with indole and pyrazole scaffolds were designed and constructed via a [3+2]cycloaddition (32CA) reaction starting from three components: new chalcone-based ... -
Aryyliamidien ja vastaavien yhdisteiden bioaktiiviset ominaisuudet
Mattila, Milla (2020)Amidit ovat yleisiä ja tärkeitä yhdisteitä biologisissa systeemeissä. Erityisesti aryyli- ja heteroaryyliamideilla on havaittu monenlaisia bioaktiivisia ominaisuuksia, joita voidaan hyödyntää esimerkiksi kipulääkkeenä, ... -
Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels
Vuornos, Kaisa; Ojansivu, Miina; Koivisto, Janne T.; Häkkänen, Heikki; Belay, Birhanu; Montonen, Toni; Huhtala, Heini; Kääriäinen, Minna; Hupa, Leena; Kellomäki, Minna; Hyttinen, Jari; Ihalainen, Janne; Miettinen, Susanna (Elsevier, 2019)Background: Due to unmet need for bone augmentation, our aim was to promote osteogenic differentiation of human adipose stem cells (hASCs) encapsulated in gellan gum (GG) or collagen type I (COL) hydrogels with bioactive ...