Effects of diet-induced obesity and voluntary wheel running on the microstructure of the murine distal femur

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dc.contributor.author Ma, Hongqiang
dc.contributor.author Turpeinen, Tuomas
dc.contributor.author Silvennoinen, Mika
dc.contributor.author Torvinen, Sira
dc.contributor.author Rinnankoski-Tuikka, Rita
dc.contributor.author Kainulainen, Heikki
dc.contributor.author Timonen, Jussi
dc.contributor.author Kujala, Urho M.
dc.contributor.author Rahkila, Paavo
dc.contributor.author Suominen, Harri
dc.date.accessioned 2011-05-13T08:12:34Z
dc.date.available 2011-05-13T08:12:34Z
dc.date.issued 2011
dc.identifier.citation Ma, H., Turpeinen, T., Silvennoinen, M., Torvinen, S., Rinnankoski-Tuikka, R., Kainulainen, H., Timonen, J., Kujala, U., Rahkila, P. & Suominen, H. (2011). Effects of diet-induced obesity and voluntary wheel running on the microstructure of the murine distal femur. Nutrition & Metabolism, 8:1. Retrieved from http://www.nutritionandmetabolism.com/content/8/1/1
dc.identifier.issn 1743-7075
dc.identifier.uri http://hdl.handle.net/123456789/26963
dc.description.abstract Background. Obesity and osteoporosis, two possibly related conditions, are rapidly expanding health concerns in modern society. Both of them are associated with sedentary life style and nutrition. To investigate the effects of diet-induced obesity and voluntary physical activity we used high resolution micro-computed tomography (μCT) together with peripheral quantitative computed tomography (pQCT) to examine the microstructure of the distal femoral metaphysis in mice. Methods. Forty 7-week-old male C57BL/6J mice were assigned to 4 groups: control (C), control + running (CR), high-fat diet (HF), and high-fat diet + running (HFR). After a 21-week intervention, all the mice were sacrificed and the left femur dissected for pQCT and μCT measurements. Results. The mice fed the high-fat diet showed a significant weight gain (over 70% for HF and 60% for HFR), with increased epididymal fat pad mass and impaired insulin sensitivity. These obese mice had significantly higher trabecular connectivity density, volume, number, thickness, area and mass, and smaller trabecular separation. At the whole bone level, they had larger bone circumference and cross-sectional area and higher density-weighted maximal, minimal, and polar moments of inertia. Voluntary wheel running decreased all the cortical bone parameters, but increased the trabecular mineral density, and decreased the pattern factor and structure model index towards a more plate-like structure. Conclusions. The results suggest that in mice the femur adapts to obesity by improving bone strength both at the whole bone and micro-structural level. Adaptation to running exercise manifests itself in increased trabecular density and improved 3D structure, but in a limited overall bone growth en
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries Nutrition & Metabolism
dc.rights © 2011 Ma et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/2
dc.title Effects of diet-induced obesity and voluntary wheel running on the microstructure of the murine distal femur
dc.type Article en
dc.identifier.urn URN:NBN:fi:jyu-2011051310802
dc.subject.kota 314
dc.contributor.laitos Terveystieteiden laitos fi
dc.contributor.laitos Department of Health Sciences en
dc.type.uri http://purl.org/eprint/type/JournalArticle
dc.identifier.doi doi:10.1186/1743-7075-8-1
dc.description.version Publisher's PDF
eprint.status http://purl.org/eprint/type/status/PeerReviewed

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