Component screening for novel xeno-free medium for human embryonic stem cells
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Decorin Expression and Oncosuppression in Human Embryonic Carcinomas
Sainio, Annele; Pennanen, Mirka; Laine, Jukka; Lund, Riikka; Söderström, Mirva; Kuopio, Teijo; Järveläinen, Hannu (Fortune Journals, 2019)Human embryonic stem cells in culture can transform into malignant, cancer-like cells exhibiting lesser differentiation. After transplantation, these transformed cells can form highly malignant germ cell tumors. In humans, ... -
Technology in culture : a theoretical discourse on convergence in human-technology interaction
Pineda, Roger G. (University of Jyväskylä, 2014)Technology touches so many facets of contemporary life that one is not necessarily conscious any more of how and why it affects daily experience. Awareness of technology’s role often surfaces only when something goes wrong ... -
Fragment‐ and Negative Image‐Based Screening of Phosphodiesterase 10A Inhibitors
Jokinen, Elmeri M.; Postila, Pekka A.; Ahinko, Mira; Niinivehmas, Sanna; Pentikäinen, Olli T. (Wiley-Blackwell Publishing, Inc., 2019)A novel virtual screening methodology called fragment‐ and negative image‐based (F‐NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A‐specific ... -
Burst analysis tool for developing neuronal networks exhibiting highly varying action potential dynamics
Kapucu, Fikret E.; Tanskanen, Jarno M. A.; Mikkonen, Jarno; Ylä-Outinen, Laura; Narkilahti, Susanna; Hyttinen, Jari A. K. (Frontiers Research Foundation, 2012)In this paper we propose a firing statistics based neuronal network burst detection algorithm for neuronal networks exhibiting highly variable action potential dynamics. Electrical activity of neuronal networks is generally ... -
Phenotypic plasticity in growth and fecundity induced by strong population fluctuations affects reproductive traits of female fish
Karjalainen, Juha; Urpanen, Olli; Keskinen, Tapio; Huuskonen, Hannu; Sarvala, Jouko; Valkeajärvi, Pentti; Marjomäki, Timo (John Wiley & Sons Ltd., 2016)Fish are known for their high phenotypic plasticity in life-history traits in relation to environmental variability, and this is particularly pronounced among salmonids in the Northern Hemisphere. Resource limitation ...