Mechanochemical Difluoromethylations of Alcohols
Abstrakti
Difluoromethyl ethers are formed through mechanochemical reactions of alcohols with difluorocarbene in a mixer mill. The protocol could be applied to primary, secondary, and tertiary alcohols, yielding the corresponding products in excellent yields (up to 99%) after 1 h reaction time at room temperature. The transformations proceeded under solvent-free reaction conditions, followed by product purification by filtration, which drastically reduced the amount of waste generated during the process.
Päätekijät
Aineistotyyppi
Artikkelit
Tutkimusartikkeli
Julkaistu
2023
Sarja
Aiheet
Julkaisu tutkimustietojärjestelmässä
Julkaisija
Chinese Chemical Society
Julkaisun pysyvä osoite
https://urn.fi/URN:NBN:fi:jyu-202308244740Käytä tätä linkitykseen
Vertaisarvioinnin tila
Vertaisarvioitu
ISSN
2096-5745
DOI
https://doi.org/10.31635/ccschem.023.202302783
Kieli
englanti
Julkaisussa
CCS chemistry
Viite
- van Bonn, P., Ke, J., Weike, C., Ward, J. S., Rissanen, K., & Bolm, C. (2023). Mechanochemical Difluoromethylations of Alcohols. CCS chemistry, 5(8), 1737-1744. https://doi.org/10.31635/ccschem.023.202302783
Lisenssi
Lisätietoja rahoituksesta
This research was made possible by the generous support of the Rhine-Westphalia Technical University of Aachen (RWTH Aachen University). We also acknowledge the Alexander von Humboldt Foundation for support of K. R. (AvH research award).
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