N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis
Abstrakti
Seven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine
E (2), toussaintine F (6), and toussaintine G (7), were isolated from
the methanol extract of the leaves of Toussaintia orientalis using column
chromatography and HPLC. The configurations of E-toussaintine E (1) and
toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction
data from racemic crystals. Both the crude methanol extract and the isolated
constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the
H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic
(ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast
cancer cell line.
Päätekijät
Aineistotyyppi
Artikkelit
Tutkimusartikkeli
Julkaistu
2015
Sarja
Aiheet
Julkaisu tutkimustietojärjestelmässä
Julkaisija
American Society of Pharmacognosy
Julkaisun pysyvä osoite
https://urn.fi/URN:NBN:fi:jyu-201606303417Käytä tätä linkitykseen
Vertaisarvioinnin tila
Vertaisarvioitu
ISSN
0163-3864
DOI
https://doi.org/10.1021/acs.jnatprod.5b00356
Kieli
englanti
Julkaisussa
Journal of Natural Products
Viite
- Nyandoro, S. S., Ndanu, J., Munissi, J. J. E., Gruhonjic, A., Fitzpatrick, P. A., Landberg, G., Lu, Y., Wang, B., Pan, F., Rissanen, K., & Erdélyi, M. (2015). N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis. Journal of Natural Products, 78(8), 2045-2050. https://doi.org/10.1021/acs.jnatprod.5b00356
Lisenssi
Copyright© the Authors, 2015. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.