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Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?

Abstract
Background: Leucocyte telomere length (LTL) is known to be associated with mortality, but its association with age-related decline in physical functioning and the development of disability is less clear. This study examined the associations between LTL and physical functioning, and investigated whether LTL predicts level of physical functioning over an 11- year follow-up. Methods: Older mono- (MZ) and dizygotic (DZ) twin sisters (n=386) participated in the study. Relative LTL was measured by qPCR at baseline. Physical functioning was measured by 6-min walking distance and level of physical activity (PA). Walking distance was measured at baseline and at 3-year follow-up. PA was assessed by questionnaire at baseline and at 3- and 11-year follow-ups. The baseline analysis was performed with path models, adjusted with age and within-pair dependence of twin pairs. The longitudinal analysis was performed with a repeated measures linear model adjusted for age and longitudinal within-pair dependence. A non-random missing data analysis was utilized. Results: At baseline, in all individuals LTL was associated with PA (est. 0.14 SE 0.06 p=0.011), but not with walking distance. Over the follow-up, a borderline significant association was observed between LTL and walking distance (est. 0.14 SE 0.07 p=0.060) and a significant association between LTL and PA (est. 0.19 SE 0.06 p=0.001). Conclusions: The results suggest that LTL is associated with PA and may, therefore, serve as a biomarker predicting the development of disability. Longitudinal associations between LTL and PA were observed only when nonrandom data missingness was taken into account in the analysis.
Main Authors
Sillanpää, Elina Törmäkangas, Timo Rantanen, Taina Kaprio, Jaakko Sipilä, Sarianna
Format
Articles Research article
Published
2016
Series
AGE
Subjects
telomere
twin study
six-minute walking test
physical activity
biological aging
missing data not at random
fyysinen toimintakyky
Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/25594130
Publisher
Springer Netherlands; American Aging Association
The permanent address of the publication
https://urn.fi/URN:NBN:fi:jyu-201603141840Use this for linking
Review status
Peer reviewed
ISSN
2452-0756
DOI
https://doi.org/10.1007/s11357-016-9898-x
Language
English
Published in
AGE
Citation
  • Sillanpää, E., Törmäkangas, T., Rantanen, T., Kaprio, J., & Sipilä, S. (2016). Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?. AGE, 38(2), Article 34. https://doi.org/10.1007/s11357-016-9898-x
License
Open Access
Copyright© American Aging Association 2016. This is a final draft version of an article whose final and definitive form has been published by Springer. Published in this repository with the kind permission of the publisher.

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author Sillanpää, Elina Törmäkangas, Timo Rantanen, Taina Kaprio, Jaakko Sipilä, Sarianna
author_facet Sillanpää, Elina Törmäkangas, Timo Rantanen, Taina Kaprio, Jaakko Sipilä, Sarianna
converis_txtF yes
departments_txtF_mv Terveystieteiden laitos Department of Health Sciences
description Background: Leucocyte telomere length (LTL) is known to be associated with mortality, but its association with age-related decline in physical functioning and the development of disability is less clear. This study examined the associations between LTL and physical functioning, and investigated whether LTL predicts level of physical functioning over an 11- year follow-up. Methods: Older mono- (MZ) and dizygotic (DZ) twin sisters (n=386) participated in the study. Relative LTL was measured by qPCR at baseline. Physical functioning was measured by 6-min walking distance and level of physical activity (PA). Walking distance was measured at baseline and at 3-year follow-up. PA was assessed by questionnaire at baseline and at 3- and 11-year follow-ups. The baseline analysis was performed with path models, adjusted with age and within-pair dependence of twin pairs. The longitudinal analysis was performed with a repeated measures linear model adjusted for age and longitudinal within-pair dependence. A non-random missing data analysis was utilized. Results: At baseline, in all individuals LTL was associated with PA (est. 0.14 SE 0.06 p=0.011), but not with walking distance. Over the follow-up, a borderline significant association was observed between LTL and walking distance (est. 0.14 SE 0.07 p=0.060) and a significant association between LTL and PA (est. 0.19 SE 0.06 p=0.001). Conclusions: The results suggest that LTL is associated with PA and may, therefore, serve as a biomarker predicting the development of disability. Longitudinal associations between LTL and PA were observed only when nonrandom data missingness was taken into account in the analysis.
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spellingShingle Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up? Sillanpää, Elina Törmäkangas, Timo Rantanen, Taina Kaprio, Jaakko Sipilä, Sarianna telomere twin study six-minute walking test physical activity biological aging missing data not at random fyysinen toimintakyky AGE
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title Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?
title_full Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?
title_fullStr Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?
title_full_unstemmed Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?
title_short Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?
title_sort Does telomere length predict decline in physical functioning in older twin sisters during an 11year followup
topic telomere twin study six-minute walking test physical activity biological aging missing data not at random fyysinen toimintakyky
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