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dc.contributor.authorHerranen, Päivi
dc.contributor.authorKoivunen, Kaisa
dc.contributor.authorPalviainen, Teemu
dc.contributor.authorKujala, Urho M.
dc.contributor.authorRipatti, Samuli
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorSillanpää, Elina
dc.contributor.authorFinnGen
dc.date.accessioned2024-04-17T09:24:47Z
dc.date.available2024-04-17T09:24:47Z
dc.date.issued2024
dc.identifier.citationHerranen, Päivi, Koivunen, Kaisa, Palviainen, Teemu, Kujala, Urho M., Ripatti, Samuli, Kaprio, Jaakko, Sillanpää, Elina, FinnGen. (2024). Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan : A Prospective Cohort Study. <i>Journals of Gerontology Series A: Biological Sciences and Medical Sciences</i>, <i>79</i>(4), Article glae064. <a href="https://doi.org/10.1093/gerona/glae064" target="_blank">https://doi.org/10.1093/gerona/glae064</a>
dc.identifier.otherCONVID_207603856
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/94350
dc.description.abstractBackground We used a polygenic score for hand grip strength (PGS HGS) to investigate whether genetic predisposition for higher muscle strength predicts age-related noncommunicable diseases, survival from acute adverse health events, and mortality. Methods This study consisted of 342 443 Finnish biobank participants from FinnGen Data Freeze 10 (53% women) aged 40 to 108 with combined genotype and health registry data. Associations between PGS HGS and a total of 27 clinical endpoints were explored with linear or Cox regression models. Results A higher PGS HGS was associated with a reduced risk of selected common noncommunicable diseases and mortality by 2% to 10%. The risk for these medical conditions decreased by 5–23% for participants in the highest PGS HGS quintile compared to those in the lowest PGS HGS quintile. A one standard deviation (SD) increase in the PGS HGS predicted a lower body mass index (BMI) (β = −0.112 kg/m2, standard error (SE) = 0.017, P = 1.69E-11) in women but not in men (β = 0.004 kg/m2, P = 0.768). PGS HGS was not associated with better survival after acute adverse health events compared to the non-diseased period. Conclusions The genotype that supports higher muscle strength appears to protect against future health adversities, albeit with modest effect sizes. Further research is needed to investigate whether or how a favourable lifestyle modifies this intrinsic capacity to resist diseases, and if the impacts of lifestyle behaviour on health differ due to genetic predisposition for muscle strength.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.relation.ispartofseriesJournals of Gerontology Series A: Biological Sciences and Medical Sciences
dc.rightsCC BY 4.0
dc.subject.othergenetics
dc.subject.otherhand grip strength
dc.subject.otherprediction
dc.subject.othernoncommunicable diseases
dc.subject.otherFinnGen
dc.titleGenome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan : A Prospective Cohort Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202404172969
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn1079-5006
dc.relation.numberinseries4
dc.relation.volume79
dc.type.versionpublishedVersion
dc.rights.copyright© 2024 the Authors
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber341750
dc.relation.grantnumber346509
dc.subject.ysoperinnöllisyystiede
dc.subject.ysoennusteet
dc.subject.ysopuristusvoima
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p5147
jyx.subject.urihttp://www.yso.fi/onto/yso/p3297
jyx.subject.urihttp://www.yso.fi/onto/yso/p25078
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1093/gerona/glae064
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundinginformationThis work was supported by the Research Council of Finland (grants 341750 and 346509 to ES, 336823 to JK), the Juho Vainio Foundation (ES), the Päivikki and Sakari Sohlberg Foundation (ES), and the JYU.Well - School of Wellbeing of the University of Jyväskylä (K.K.)
dc.type.okmA1


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