Glyoxalase-based toolbox for the enantioselective synthesis of α-hydroxy carboxylic acids
| dc.contributor.author | Yedigenov, Mussa | |
| dc.contributor.author | Amire, Niyaz | |
| dc.contributor.author | Abdirassil, Aizat | |
| dc.contributor.author | Mulikova, Tomiris | |
| dc.contributor.author | Begenov, Azamat | |
| dc.contributor.author | Kiesilä, Anniina | |
| dc.contributor.author | Peshkov, Anatoly A. | |
| dc.contributor.author | Peshkov, Vsevolod A. | |
| dc.contributor.author | Utepbergenov, Darkhan | |
| dc.date.accessioned | 2024-03-20T12:16:31Z | |
| dc.date.available | 2024-03-20T12:16:31Z | |
| dc.date.issued | 2024 | |
| dc.identifier.citation | Yedigenov, M., Amire, N., Abdirassil, A., Mulikova, T., Begenov, A., Kiesilä, A., Peshkov, A. A., Peshkov, V. A., & Utepbergenov, D. (2024). Glyoxalase-based toolbox for the enantioselective synthesis of α-hydroxy carboxylic acids. <i>Organic and Biomolecular Chemistry</i>, <i>Advance Article</i>. <a href="https://doi.org/10.1039/D3OB02098C" target="_blank">https://doi.org/10.1039/D3OB02098C</a> | |
| dc.identifier.other | CONVID_207171021 | |
| dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/93987 | |
| dc.description.abstract | We report highly enantioselective synthesis of L-α-hydroxy carboxylic acids (L-αHCAs) via enzymatic intramolecular Cannizzaro reaction of (hetero)aryl glyoxals in the presence of glutathione-independent human glyoxalase DJ-1. Combined with the optimized synthesis of D-αHCAs using glyoxalases I and II, this approach offers a general, scalable and operationally simple access to both enantiomers of α-hydroxy acids in moderate to excellent yields with uniformly high enantioselectivity. | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | eng | |
| dc.publisher | Royal Society of Chemistry | |
| dc.relation.ispartofseries | Organic and Biomolecular Chemistry | |
| dc.rights | In Copyright | |
| dc.subject.other | glyoksalaasi | |
| dc.subject.other | glyoxalase | |
| dc.title | Glyoxalase-based toolbox for the enantioselective synthesis of α-hydroxy carboxylic acids | |
| dc.type | article | |
| dc.identifier.urn | URN:NBN:fi:jyu-202403202526 | |
| dc.contributor.laitos | Kemian laitos | fi |
| dc.contributor.laitos | Department of Chemistry | en |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
| dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.description.reviewstatus | peerReviewed | |
| dc.relation.issn | 1477-0520 | |
| dc.relation.volume | Advance Article | |
| dc.type.version | acceptedVersion | |
| dc.rights.copyright | © 2024 Royal Society of Chemistry | |
| dc.rights.accesslevel | embargoedAccess | fi |
| dc.subject.yso | orgaaninen kemia | |
| dc.subject.yso | synteesi | |
| dc.subject.yso | entsyymit | |
| dc.subject.yso | karboksyylihapot | |
| dc.format.content | fulltext | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p11902 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p8467 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p4769 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p27282 | |
| dc.rights.url | http://rightsstatements.org/page/InC/1.0/?language=en | |
| dc.relation.doi | 10.1039/D3OB02098C | |
| jyx.fundinginformation | This work was supported by Nazarbayev University CRP grant 091019CRP2121 to D. U. and FDCRGP grant 11022021FD2903 to V. P. | |
| dc.type.okm | A1 |
Aineistoon kuuluvat tiedostot
Aineisto kuuluu seuraaviin kokoelmiin
Ellei muuten mainita, aineiston lisenssi on In Copyright